2026-10-19T01:08:53Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/142782026-10-18T20:33:40Zopenairedrivercom_ebyu_10000col_ebyu_10001The ameliorative effect of lutein on ovarian ischemiareperfusion injury in ratsTurkler, C.Kulhan, N.G.Ata, N.Kiremitli, T.Cimen, F. KeskinSuleyman, H.Ischemia-reperfusionLuteinOvaryRatAnimalsAntioxidantsFemaleMalondialdehydeRandom AllocationRatsRats, WistarReperfusion InjuryantioxidantmalonaldehydexanthophyllanimalrandomizationvascularizationWistar ratOBJECTIVES: The aim of our study is to investigate biochemical and histopathological effects of lutein on the ovarian ischemia-reperfusion (I/R) injury in rats. BACKGROUND: Reactive oxygen species and cytokines have a very important role in the pathogenesis of I/R injury. Lutein and its derivatives may show an anti-infl ammatory effect in relation to the decrease in infl ammatory cytokines and increase in antioxidant enzymes. METHODS: Wistar albino female rats were randomly divided into three groups before surgery as follows: I/R group (IRG; n = 6), 1 mg/kg lutein + I/R group (LIRG; n = 6), and a healthy control group scheduled for a sham operation (SG; n = 6). The condition of ovarian ischemia was created by vascular clips. After two hours, the ovary was reperfused. Then, cyclooxygenase-1, cyclooxygenase-2, malondialdehyde and total glutathione levels were examined in ovary tissues of rats. RESULTS: As the results of our study demonstrated, in ovarian tissues of animals after I/R, there was an increase in the levels of malondialdehyde and cyclooxygenase-2, while total glutathione and cyclooxygenase-1 were decreased. At the same time, it has been observed however that these ratios are reversed in the LIRG group (p < 0.05). CONCLUSION: Lutein ameliorates the I/R-induced ovarian injury in rats by its antioxidative and anti-infl ammatory activities (Fig. 2, Ref. 39). Text in PDF www.elis.sk. © AEPress s.r.o.Comenius University2018Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14278https://doi.org/10.4149/bll_2018_1270006-9248enBratislava Medical Journalinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14278