2026-10-19T01:03:13Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/143082026-10-18T21:14:22Zopenairedrivercom_ebyu_10000col_ebyu_10001The Effect of the 50 g Glucose Challenge Test on The Thiol/Disulfide Homeostasis in PregnancyMertoğlu, CumaGunay, MuratSiranli, GulsahKulhan, MehmetGok, GamzeErel, Özcan50 g glucose challenge testGestational diabetes mellitusOral glucose tolerance testOxidative stressThiol/disulfide homeostasisAdultBlood GlucoseCase-Control StudiesDiabetes, GestationalDisulfidesFemaleGlucose Tolerance TestHomeostasisHumansPregnancyProspective StudiesSulfhydryl Compoundsdisulfideglucosethiolthiol derivativeArticlebody masscase control studycontrolled studydisulfide bondglucose challenge testhumanmaternal agepregnancy diabetes mellitusAim: A 50 g glucose challenge test (GCT) is recommended for screening all pregnant women for gestational diabetes mellitus. In this study, the effect of GCT on the thiol/disulfide balance was investigated. Methods: One-hundred women that underwent a 50 g GCT at 24–28 weeks of gestation (63 positive and 37 negative results) were evaluated in terms of thiol/disulfide in serum samples at test hours 0 and 1. Results: Compared to the baseline values (hour 0), after the glucose load (hour 1), the thiol and native thiol/total thiol (p < 0.0001) of the GCT-positive women were reduced whereas the values of glucose, disulfide, disulfide/native thiol, disulfide/total thiol (p < 0.0001) and total thiol increased (p = 0.018). Conclusion: In GCT-positive pregnant individuals, the glucose load increases oxidative stress by changing the thiol/disulfide homeostasis. Such an effect is not observed in healthy pregnancies. © 2018, © 2018 Taylor & Francis Group, LLC.Taylor and Francis Ltd2018Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14308https://doi.org/10.1080/15513815.2018.14530021551-3815enFetal and Pediatric Pathologyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14308