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Synthesis, characterization, antioxidant, antidiabetic, anticholinergic, and antiepileptic properties of novel N-substituted tetrahydropyrimidines based on phenylthioureaMaharramova, GunelTaslimi, ParhamSujayev, AfsunFarzaliyev, VagifDurmaz, LokmanGulçin, İlhamiacetylcholinesteraseantioxidant activitybutyrylcholinesterasecarbonic anhydrasephenylthioureaAnticonvulsantsAntioxidantsCarbon-13 Magnetic Resonance SpectroscopyCarbonic Anhydrase ICarbonic Anhydrase IICarbonic Anhydrase InhibitorsCholinergic AntagonistsCholinesterase InhibitorsCrystallography, X-RayGlycoside Hydrolase InhibitorsGlycoside HydrolasesHumansHypoglycemic AgentsIsoenzymesModels, MolecularProton Magnetic Resonance SpectroscopyPyrimidinesStructure-Activity Relationship1 [4 (2 hydroxyphenyl) 6 methyl 1 phenyl 2 thioxo 1,2,3,4 tetrahydropyrimidin 5 yl]ethanoneacarboseacetazolamidealpha glycosidasealpha tocopherolanticonvulsive agentantidiabetic agentIn the presence of trifluoroacetic acid, on the basis of three-component condensation of phenylthiourea with its salicylaldehyde and methyl-3-oxobutanoate, an efficient method for the synthesis of 1-(4-(2-hydroxyphenyl)-6-methyl-1-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)ethanone (I) has been worked out. These novel N-substituted tetrahydropyrimidines based on phenylthiourea showed good inhibitory action against acetylcholinesterase (AChE), α-glycosidase, and human carbonic anhydrase (hCA) isoforms I and II. K i values of AChE enzyme were in the range of 0.48 to 7.46 nM. The hCA I and II were effectively inhibited by the compounds, with K i values in the range of 502.44 to 923.11 nM for hCA I and 400.32 to 801.57 nM for hCA II, respectively. The antioxidant activity of the novel N-substituted tetrahydropyrimidines based on phenylthiourea was investigated by using different in vitro antioxidant assays; including 1,1-diphenyl-2-picrylhydrazyl (DPPH·) radical scavenging, Cu 2+ and Fe 3+ reducing activities. © 2018 Wiley Periodicals, Inc.John Wiley and Sons Inc.2018Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14355https://doi.org/10.1002/jbt.222211095-6670enJournal of Biochemical and Molecular Toxicologyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14355