2026-10-19T06:17:07Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/143892026-10-18T21:14:22Zopenairedrivercom_ebyu_10000col_ebyu_10001The effect of rutin on ovarian ischemia-reperfusion injury in a rat modelNayki, CenkNayki, UmitKeskin Cimen, FerdaKulhan, MehmetYapca, Omer ErkanKurt, NezahatBilgin Ozbek, Aslıinflammationischemia-reperfusionOvaryoxidative stressrutinAnimalsAntioxidantsFemaleInjections, IntraperitonealInterleukin-1betaMalondialdehydeOvarian DiseasesRatsRats, WistarReperfusion InjuryTumor Necrosis Factor-alphacyclooxygenase 1cyclooxygenase 2glutathioneinterleukin 1betamalonaldehyderutosidetumor necrosis factorantioxidantanimal experimentanimal modelanimal tissueantiinflammatory activityantioxidant activityArticleThe effect of rutin on ovarian ischemia-reperfusion (I/R) injury was investigated in this experimental study. Eighteen Wistar albino female rats were divided into three groups as follows: I/R group (IRG; n = 6), 50 mg/kg rutin + I/R group (RG; n = 6), and a healthy control group scheduled for a sham operation (SG; n = 6). 2 h of ischemia and following 2 h of reperfusion were created in the IRG and RG by using a torsion model involving atraumatic vascular clips. Rutin, a flavonoid glycoside, was injected intraperitoneally at the dose of 50 mg/kg to RG group 1 h before reperfusion. Then, rats were euthanized and their ovaries were removed for biochemical and histopathological examination and also assessment of the gene expressions. IRG group had a significant increase in malondialdehyde (MDA) levels, in the expressions of tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β), and also in the activity of cyclooxygenase 2 (COX-2) unlike the significant decrease in total glutathione (tGSH) levels and the activity of COX-1 when compared to the SG group. However, rutin significantly decreased MDA levels, the expressions of TNF-α and IL-1β, and also the activity of COX-2 while it increased significantly tGSH levels and the activity of COX-1 in the RG group in comparison with the IRG group. Rutin ameliorated the I/R-induced ovarian injury in rats via its possible antioxidative and anti-inflammatory effects. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.Taylor and Francis Ltd2018Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14389https://doi.org/10.1080/09513590.2018.14503780951-3590enGynecological Endocrinologyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14389