2026-10-19T01:06:26Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/request

oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/143962026-10-18T21:13:30Zopenairedrivercom_ebyu_10000col_ebyu_10001

Effect of ethyl acetate extract of usnea longissima o esophagogastric adenocarcinoma in ratsMammadov, RenadSuleyman, BahadirAltuner, DurduDemirci, ElifCetin, NihalYilmaz, AdnanBaykal, HuseyinAlpcan, HilalTurumtay, Emine AkyuzSuleyman, HalisAcetatesAdenocarcinomaRatsUsneaAnimalsAntineoplastic Agents, PhytogenicMaleNeoplasms, ExperimentalPlant ExtractsRats, WistarStomach Neoplasmsacetic acid ethyl esteralanine aminotransferaseaspartate aminotransferasecisplatincreatine kinasecreatininecytokeratinfungal extractmethylnitronitrosoguanidinetroponin Iunclassified drugusnea longissima extractusnic acidvimentinacetic acidantineoplastic agentplant extractanimal experimentanimal modelPurpose: To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG). Methods: The anticancer activity of EtOAc extract of U. longissima was examined in the esophagogastric adenocarcinoma models induced in rats with MNNG. EtOAc extract of U. longissima, 50 and 100 mg/kg oral doses were administered once daily for six months. MNNG induced differentiated and undifferentiated type adenocarcinomas in the esophageal and gastric tissues of rats. Results: EtOAc extract of U. longissima obtained from U. longissima prevented gastric and esophageal cancerogenesis induced in rats with MNNG. EtOAc extract of U. longissima did not have a lethal effect at doses of 500, 1000 and 2000 mg/kg. The prominent anticarcinogenic activity of EtOAc extract of U. longissima 50 and 100 mg/kg suggests that it is not toxic and it is selective to the cancer tissue. Conclusion: This information may shed light on clinical implementation of EtOAc extract of U. longissima in future. © 2019, Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia. All rights reserved.Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia2019Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14396https://doi.org/10.1590/s0102-8650201900300000050102-8650enActa Cirurgica Brasileirainfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14396