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Synthesis of 2-amino-3-cyanopyridine derivatives and investigation of their carbonic anhydrase inhibition effectsAltundas, AliyeGül, BernaÇankaya, MuratAtasever, AliGülçin, İlhami2-amino-3-cyanopyridinecarbonic anhydraseenzyme inhibitionenzyme purificationAminopyridinesCarbonic Anhydrase InhibitorsCarbonic AnhydrasesHumansKinetics2 amino 3 cyanopyridine derivative2 amino 4 (5 methylfuran 2 yl)furo[2,3 h]quinolin 3 carbonitrile2 amino 4 (5 methylfuran 2 yl)thieno[2,3 h] quinolin 3 carbonitrile2 amino 5,6 dihydro 4 (5 methylfuran 2 yl)furo[2,3 h]quinolin 3 carbonitrile2 amino 5,6 dihydro 4 (5 methylfuran 2 yl)thio[2,3 h]quinolin 3 carbonitrile2 amino 5,6 dihydro 9 methoxy 4 (5 methylfuran 2 yl)benzo[h]quinolin 3 carbonitrile2 amino 5,6,7,8 tetrahydro 4 (4 methylthiazol 2 yl)quinolin 3 carbonitrile2 amino 5,6,7,8 tetrahydro 4 (5 methylfuran 2 yl)quinolin 3 carbonitrile2 amino 5,7 dihydro 7 methyl 4 (5 methylfuran 2 yl)furo[3,4 b]pyridine 3 carbonitrile2 amino 6,7,8,9 tetrahydro 4 (5 methylfuran 2 yl) 5h cyclohepta[b]pyridine 3 carbonitrile2 amino 6,8 dihydro 4 (4 methylthiazol 2 yl) 5h pyrano[3,4 b]pyridine 3 carbonitrile2 amino 6,8 dihydro 4 (4 methylthiazol 2 yl) 5h thiopyrano[3,4 b]pyridine 3 carbonitrile2 amino 9 methoxy 4 (5 methylfuran 2 yl)benzo[h]quinoline 3 carbonitrile3 (aminomethyl) 4 (5 methylfuran 2 yl) 5,6,7,8 tetrahydronaphthalene 2 amine3 (aminomethyl) 4 (5 methylfuran 2 yl) 6,7,8,9 tetrahydro 5h cylohepta[b]pyridin 2 aminecarbonate dehydratase Icarbonate dehydratase IIcarbonate dehydratase inhibitorpyridine derivativesepharoseunclassified drugThe conversion of carbon dioxide (CO2) and bicarbonate (HCO3 −) to each other is very important for living metabolism. Carbonic anhydrase (CA, E.C.4.2.1.1), a metalloenzyme familly, catalyzes the interconversion of these ions (CO2 and HCO3 −) and are very common in living organisms. In this study, a series of novel 2-amino-3-cyanopyridines supported with some functional groups was synthesized and tested as potential inhibition effects against both cytosolic human CA I and II isoenzymes (hCA I and II) using by Sepharose-4B-l-tyrosine-sulfanilamide affinity chromatography. The structural elucidations of novel 2-amino-3-cyanopyridines were achieved by NMR, IR, and elemental analyses. Ki values of the novel synthesized compounds were found in range of 2.84–112.44 μM against hCA I and 2.56–31.17 μM against hCA II isoenzyme. While compound 7d showed the best inhibition activity against hCA I (Ki: 2.84 μM), the compound 7b demonstrated the best inhibition profile against hCA II isoenzyme (Ki: 2.56 μM). © 2017 Wiley Periodicals, Inc.John Wiley and Sons Inc.2017Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14411https://doi.org/10.1002/jbt.219981095-6670enJournal of Biochemical and Molecular Toxicologyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14411