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Damage induced by paracetamol compared with N-acetylcysteineKisaoglu, AbdullahOzogul, BunyamiTuran, Mehmet IbrahimYilmaz, IsmayilDemiryilmaz, IsmailAtamanalp, Sabri SelcukBakan, EbubekirSuleyman, HalisHepatotoxicityParacetamolRatThiamineThiamine pyrophosphateAcetaminophenAcetylcysteineAlanine TransaminaseAnimalsAspartate AminotransferasesGlutathioneL-Lactate DehydrogenaseLiverMaleRatsRats, Wistarcatalasecocarboxylaseglutaredoxinglutathione peroxidaseglutathione transferasemalonaldehydenitric oxidesuperoxide dismutasealanine aminotransferaseaspartate aminotransferaselactate dehydrogenaseanimal experimentanimal modelArticleBackground: This study investigated the effect of thiamine pyrophosphate (TPP) on oxidative liver damage induced in rats with high-dose paracetamol. Methods: Rats for this experiment were divided into the following groups: healthy control, paracetamol control, thiamine+paracetamol, TPP+paracetamol, and N-acetylcysteine+paracetamol. Oxidant and antioxidant parameters and liver function test levels were compared between the groups. Results: The results show that TPP and N-acetylcysteine with paracetamol equally prevented a rise in oxidants such as malondialdehyde and nitric oxide. They also prevented a decrease in enzymatic and nonenzymatic antioxidants such as glutathione, glutathione peroxidase, glutaredoxin, glutathione S-transferase, superoxide dismutase, and catalase in the rat liver. Conclusion: Thiamine pyrophosphate and N-acetylcysteine had a similar positive effect on oxidative damage caused by paracetamol hepatotoxicity. These findings show that TPP may be beneficial in paracetamol hepatotoxicity. © 2014.Elsevier Ltd2014Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14457https://doi.org/10.1016/j.jcma.2014.01.0111726-4901enJournal of the Chinese Medical Associationinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14457