2026-10-19T01:18:25Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/144632026-10-18T21:14:21Zopenairedrivercom_ebyu_10000col_ebyu_10001Serum NT-pro CNP levels in epileptic seizure, psychogenic non-epileptic seizure, and healthy subjectsCeylan, MustafaYalcin, AhmetBayraktutan, Omer FarukLaloglu, EsraBiomarkerEpilepsyNT-pro CNPPsychogenic non-epileptic seizureAdolescentAdultElectroencephalographyFemaleHealthy VolunteersHumansMaleMiddle AgedNatriuretic Peptide, C-TypePsychophysiologic DisordersSeizuresStatistics, NonparametricVideo RecordingYoung Adultbiological markernatriuretic peptide type Camino terminal sequenceArticleblood brain barrierbrain microcirculationclinical evaluationcontrolled studyexcitationhumanmajor clinical studyneurophysiologyPurpose: Epileptic seizure is the result of uncontrollable neural excitation in the brain. The C-type natriuretic peptide is a member of natriuretic peptide hormone family and is synthesized by brain and blood vessels in CNS. NT-pro CNP is an amino-terminal fragment of C-type natriuretic peptide and is more stable compared to its predecessor. In this study, we aimed to evaluate the role of NT-pro CNP in psychogenic non-epileptic seizures, epileptic seizures, and normal subjects. Methods: Thirty-three patients with epilepsy and 43 patients with psychogenic non-epileptic seizures were enrolled in this study. The control group consisted of 28 healthy subjects. Post-ictal serum levels of NT-pro CNP were acquired from all participants. Statistically significant differences between patient groups and controls regarding serum levels of NT-pro CNP were sought. Results: NT-pro CNP levels were significantly lower in the epilepsy group than the psychogenic non-epileptic seizure group and control group with no significant difference between the psychogenic non-epileptic seizure and control group (p < 0.05). Conclusion: Post-ictal serum NT-pro CNP levels were lower in epileptic seizures compared to psychogenic non-epileptic seizures as well as healthy controls. We think that such a difference is associated with C-type natriuretic peptide-related neural mechanisms such as altered microcirculation, increased brain-blood barrier permeability, and synaptic stabilization. © 2018, Springer-Verlag Italia S.r.l., part of Springer Nature.Springer-Verlag Italia s.r.l.2018Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14463https://doi.org/10.1007/s10072-018-3562-41590-1874enNeurological Sciencesinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14463