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α-amylase and α-glucosidase inhibitory activities of the extracts and constituents of ferulago blancheana, F. Pachyloba and F. Trachycarpa rootsKarakaya, SongülÖzbek, HilalGözcü, SefaGüvenalp, ZühalYuca, HafizeDuman, HayriKazaz, CavitKiliç, Ceyda SibelApiaceaeCoumarinF. pachylobaF. trachycarpaFerulago blancheanaα-Amylaseα-Glucosidaseacarbosealpha glucosidasealpha glucosidase inhibitoramylaseamylase inhibitorbergaptenfelamidinFerulago blancheana extractFerulago pachyloba extractFerulago trachycarpa extractgrandivitinolmarmesinmethoxsalenostholepentosalenplant extractprantschimginsitosterolstigmasterolsuberosinulopterolumbelliferoneunclassified drugEleven coumarins named osthole (1), imperatorin (2), bergapten (3), prantschimgin (4), grandivitinol (5), suberosin (6), xanthotoxin (7), felamidin (8), marmesin (9), umbelliferone (10), ulopterol (11), and a sterol mixture consisted of stigmasterol (12), β-sitosterol (13) were isolated from the roots of Ferulago blancheana, F. pachyloba and F. trachycarpa through in vitro bioassay-guided fractionation processes. The extracts and bioactive compounds were evaluated for their α-amylase and α-glucosidase activities. Among the tested compounds, felamidin and suberosin showed significant α-glucosidase inhibitory activity with IC50 values of 0.4 and 0.9 mg/mL, respectively, when compared to the reference standard acarbose (IC50 = 4.9 mg/mL). Grandivitinol (IC50 = 20.0 mg/mL) had the lowest inhibitory effect. On the other hand, none of the tested extracts were found to be active on α-amylase inhibition. This is the first report on isolation, characterization of the bioactive compounds and evaluation the α-amylase and α-glucosidase inhibitory activities of these species. © 2018, Bangladesh Pharmacological Society. All rights reserved.Bangladesh Pharmacological Society2018Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14481https://doi.org/10.3329/bjp.v13i1.336681991-007XenBangladesh Journal of Pharmacologyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14481