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Vitamin D supplementation does not improve plasma thiol/disulfide homeostasisMertoglu, CumaSiranli, GulsahTopal, IsmailGok, GamzeErel, Ozcanhealthy childoxidative stressthiol/disulfide homeostasisvitamin DAdolescentBiomarkersChildChild, PreschoolDietary SupplementsDisulfidesFemaleHomeostasisHumansInfantInfant, NewbornMaleSulfhydryl CompoundsTreatment OutcomeVitamin D DeficiencyVitamins25 hydroxyvitamin Ddisulfidethiolbiological markerthiol derivativevitaminadultArticleblood levelchild healthBackground: Impairment of thiol/disulfide homeostasis, as well as vitamin D deficiency, are responsible for the pathophysiology of many acute and chronic diseases. This study examined the relationship between thiol/disulfide homeostasis and vitamin D level and supplementation. Methods: A total of 203 healthy children were included in the study. The participants were divided into four groups according to 25-hydroxyvitamin D (25(OH)D) level: group 1, severe deficiency (<10 ng/mL); group 2, deficiency (10–20 ng/mL); group 3, insufficiency (20–30 ng/mL); and group 4, sufficiency (≥30 ng/mL). Furthermore, group 5 was defined as being on vitamin D supplementation. Result: Native thiol was lower in group 5 than in groups 2–4 (P = 0.003). Disulfide was higher in groups 1, 4 and 5 than groups 2 and 3 (P < 0.001). Total thiol was lower in group 5 than in group 4 (P = 0.032). The ratio of native thiol/total thiol was lower in groups 1 and 5 compared with groups 2 and 3, and in group 4 compared with group 3 (P < 0.001). The ratios of disulfide/total thiol and disulfide/native thiol were higher in groups 1 and 5 than in groups 2 and 3 whereas only the disulfide/total thiol ratio was higher in group 4 than in group 3 (P < 0.001). Conclusions: In healthy children, severe deficiency of vitamin D causes impairment of thiol/disulfide homeostasis and increases protein oxidation, which cannot be reversed by external vitamin D supplementation. © 2018 Japan Pediatric SocietyBlackwell Publishing2018Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14487https://doi.org/10.1111/ped.137051328-8067enPediatrics Internationalinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14487