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oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/145762026-10-18T20:41:14Zopenairedrivercom_ebyu_10000col_ebyu_10001

Pharmacokinetics of ceftiofur in healthy and lipopolysaccharide-induced endotoxemic newborn calves treated with single and combined therapyAltan, FerayUney, KamilEr, AyseCetin, GulDik, BurakYazar, EnverElmas, MuammerCalveCeftiofurEndotoxemiaPharmacokineticAnimalsAnimals, NewbornAnti-Bacterial AgentsCase-Control StudiesCattleCattle DiseasesCephalosporinsDrug Therapy, CombinationInjections, IntravenousLipopolysaccharidesantiinfective agentcephalosporin derivativelipopolysaccharideanimalbovinecase control studycattle diseasecombination drug therapyintravenous drug administrationmetabolismmicrobiologynewbornveterinaryThe aim of this research was to compare plasma pharmacokinetics of ceftiofur sodium (CS) in healthy calves, and in calves with experimentally induced endotoxemia. Six calves received CS (2.2 mg/kg, IM) 2 hr after intravenous administration of 0.9% NaCl (Ceft group). After a washout period, the same 6 calves received CS 2 hr after intravenous injection of lipopolysaccharide (LPS+Ceft group). Another group of 6 calves received a combination of drug therapies that included CS 2 hr after administration of 0.9% NaCl (Comb group). A third group of 6 calves received the same combination therapy regimen 2 hr after intravenous injection of lipopolysaccharide (LPS+Comb group). Plasma concentrations of CS and all desfuroylceftiofur-related metabolites were determined using HPLC, and its pharmacokinetic properties were determined based on a two-compartment model. The peak concentration of CS in the LPS+Comb group occurred the earliest, and the clearance rate of CS was the highest in the Comb and LPS+Comb groups (P<0.05). The elimination half-life of CS in the LPS+Ceft group was longer than that in the Ceft and Comb groups (P<0.05). The results of this study indicate that combined therapies and endotoxemic status may alter the plasma pharmacokinetics of CS in calves. © 2017 The Japanese Society of Veterinary Science.Japanese Society of Veterinary Science2017Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14576https://doi.org/10.1292/jvms.16-06410916-7250enJournal of Veterinary Medical Scienceinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14576