2026-10-18T23:16:12Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/146472026-10-18T21:14:25Zopenairedrivercom_ebyu_10000col_ebyu_10001Protective effect of Naringin on experimental hindlimb ischemia/reperfusion injury in ratsGürsul, CebrailEkinci Akdemir, Fazile NurAkkoyun, TuranCan, İsmailGül, MustafaGülçin, İlhamiAntioxidant enzymesischemia/reperfusion injuryNaringinreactive oxygen speciesskeletal muscleAnimalsAntioxidantsDisease Models, AnimalFlavanonesHindlimbMaleMuscle, SkeletalOxidative StressProtective AgentsRatsReperfusion Injuryaurantiinmalonaldehydeantioxidantflavanone derivativeprotective agentanimal experimentanimal modelanimal tissueantioxidant activityArticlecontrolled studyenzyme activitygastrocnemius musclehistopathologyThis study was designed to investigate the antioxidant effects of Naringin, in ischemia/reperfusion (I/R)-induced skeletal muscle injury in rats. The rats were randomly allocated into three groups including control, I/R and I/R + Naringin groups. Muscle tissues of I/R groups revealed significantly higher antioxidant enzyme activities, and increased levels of malondialdehyde, as specific a marker of the lipid peroxidation and tissue damage, compared to the control group (p < 0.05). Levels of these parameters in muscle revealed significant reductions in the I/R + Naringin group compared to the I/R group (p < 0.05). Histopathological examination of ischemia muscles in the I/R group showed significant degeneration and inflammation compared to the control group, whereas ischemic muscles of Naringin-administered group showed significant reduction in degeneration and inflammation compared to the I/R group (p < 0.05). We suggest that the protective effect of Naringin may reduce the I/R injury in cases of extremity injuries with acute vascular complications, extremity surgery with prolonged tourniquet application. © 2016 Informa UK Limited, trading as Taylor & Francis Group.Taylor and Francis Ltd2016Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14647https://doi.org/10.3109/14756366.2016.11670501475-6366enJournal of Enzyme Inhibition and Medicinal Chemistryinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14647