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Syntheses and evaluation of multicaulin and miltirone-like compounds as antituberculosis agentsBurmaoğlu, SerdarSeçinti, HaticeMozioğlu, ErkanGören, Ahmet C.Altundaş, RamazanSeçen, HasanantituberculosismiltironeMulticaulinsynthesisAntitubercular AgentsDose-Response Relationship, DrugMicrobial Sensitivity TestsMolecular StructureMycobacteriumPhenanthrenesStructure-Activity Relationship2 isopropyl 3 methoxy 9,10 dihydrophenanthrene2 isopropyl 3 methoxyphenanthrene2 isopropylphenanthren 3 ol2 isopropylphenanthren 3,4 dione4 isopropyl 3 methoxy 9,10 dihydrophenanthrenephenanthrene derivativestreptomycintuberculostatic agentunclassified drugphenanthreneantibacterial activityArticlechemical reactioncontrolled studydrug screeningdrug synthesisin vitro studyminimum inhibitory concentrationMycobacterium bovisFour multicaulin and miltirone-like phenanthrene derivatives were synthesised and evaluated as antituberculosis agents. The crucial step of the synthesis was Pschorr coupling of 4-(3-isopropyl-4-methoxyphenyl)-2-(2-aminophenyl)ethane (13) to give 2-isopropyl-3-methoxy-9,10-dihydrophenanthrene (9) and 4-isopropyl-3-methoxy-9,10-dihydrophenanthrene (9a). Compound 9 was converted to multicaulin and miltirone-like phenanthrene derivatives by further reactions. The best antituberculosis activity was exhibited by 2-isopropylphenanthrene-3-ol (11). © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.Taylor and Francis Ltd2017Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14731https://doi.org/10.1080/14756366.2017.13377581475-6366enJournal of Enzyme Inhibition and Medicinal Chemistryinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14731