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Evaluation of thiol-disulphide homeostasis in radiation workersKoc, UralTan, SinanErtem, Ahmet GoktugGumus, MehmetOzbek, BetulErel, Ozcandisulphideradiation workersThiolAdolescentAdultBiological AssayDisulfidesDose-Response Relationship, RadiationFemaleHomeostasisHumansMaleMedical Staff, HospitalMiddle AgedOccupational ExposureOxidative StressRadiation DosageRadiation ExposureReproducibility of ResultsSensitivity and SpecificitySulfhydryl CompoundsTurkeyYoung Adultfluorodeoxyglucoseiodine 131sodium borohydridetechnetium 99mthiol derivativethiol disulphideunclassified drugPurpose: To evaluate thiol-disulphide homeostasis–a novel, easily calculated, readily available, and relatively cheap oxidative stress marker–in radiation workers and compare the results with healthy controls. Materials and methods: A total of 108 participants were enrolled in the study including 63 hospital workers occupationally exposed to ionizing radiation in the units of interventional radiology, interventional cardiology and nuclear medicine. A control group consisted of 45 individuals staff in the same hospital. Serum thiol-disulphide homeostasis measurement was investigated via the spectrophotometric method newly described by Erel and Neşelioğlu. Results: The mean serum native thiol levels of radiation workers (528.96 ± 86.42 μmol/l) was significantly lower than control subjects (561.05 ± 104.83 μmol/l) (p =.045). The mean serum total thiol levels of radiation workers (547.70 ± 91.50 μmol/l) was lower than control subjects (580.36 ± 112.24 μmol/l). Nevertheless, there was no significant difference between total thiol of exposed workers and controls. Conclusions: The results show that long-term low dose ionizing radiation may lead to oxidative stress and have side-effects in antioxidant thiol groups. We may suggest supporting radiation workers by safe antioxidant nutritional formulations and following up via both physical dosimetry and biodosimetric methods. © 2017 Informa UK Limited, trading as Taylor & Francis Group.Taylor and Francis Ltd2017Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14741https://doi.org/10.1080/09553002.2017.13046680955-3002enInternational Journal of Radiation Biologyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14741