2026-10-18T23:16:31Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/request

oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/147632026-10-18T21:14:25Zopenairedrivercom_ebyu_10000col_ebyu_10001

Synthesis and anti-proliferative activity of fluoro-substituted chalconesBurmaoglu, SerdarAlgul, OztekinAnil, Derya AktasGobek, ArzuDuran, Gulay GulbolErsan, Ronak HajDuran, NizamiAnti-proliferative activityChalconeClaisen-Schmidt condensationOrganofluorineSynthesisAntineoplastic AgentsCell Line, TumorCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular StructureStructure-Activity Relationshipantineoplastic agentchalcone derivativefluorine derivativemethotrexateA375 cell lineA498 cell lineA549 cell lineanalytic methodantiproliferative activityArticlecancer cell linecarbon nuclear magnetic resonancecontrolled studydrug synthesiselemental analysisfemaleA series of novel fluoro-substituted chalcone derivatives have been synthesized. All synthesized compounds were characterized by 1H nuclear magnetic resonance (NMR), 13C NMR, and elemental analysis. Their anti-proliferative activities were evaluated against five cancer cells lines, namely, A549, A498, HeLa, A375, and HepG2 using the MTT method. Most of the compounds showed moderate to high activity with IC50 values in the range of 0.029-0.729 μM. Of all the synthesized compounds, 10 and 19 exhibited the most potent anti-proliferative activities against cancer cells, and 10 was identified as the most promising compound. © 2016 Elsevier Ltd. All rights reserved.Elsevier Ltd2016Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14763https://doi.org/10.1016/j.bmcl.2016.04.0960960-894XenBioorganic and Medicinal Chemistry Lettersinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14763