2026-10-19T00:02:54Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/request

oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/149202026-10-18T21:14:24Zopenairedrivercom_ebyu_10000col_ebyu_10001

A new update for radiocontrast-induced nephropathy aggravated with glycerol in rats: The protective potential of epigallocatechin-3-gallatePalabiyik, Saziye SezinDincer, BusraCadirci, ElifCinar, IrfanGundogdu, CemalPolat, BeyzagulYayla, MuhammedHalici, ZekaiContrast mediaEGCGNephrotoxicityRatAnimalsAntioxidantsBlood Urea NitrogenCatechinCytokinesGlycerolKidneyKidney DiseasesMaleOxidative StressRatsRats, WistarTeacreatinineepigallocatechin gallateimmunoglobulin enhancer binding proteiniohexoltumor necrosis factorantioxidantcontrast mediumcytokineanimal experimentanimal modelanimal tissueArticlecontrast induced nephropathyContrast media (CM) is known to have nephrotoxic adverse effects. Epigallocatechin-3-gallate (EGCG) is the most abundant and active catechin in green tea, and has strong antioxidant and anti-inflammatory properties. This study investigated whether EGCG can reduce contrast-induced nephrotoxicity (CIN), alone or with glycerol (GLY)-induced renal damage, and to understand its mechanisms of protection against toxicity, using models of GLY and CIN in rats. The rats were separated into eight groups (n=6 in each), as follows: Healthy, GLY, CM, GLY+CM, CM+EGCG 50mg/kg (po), GLY+CM+EGCG 50mg/kg (po), CM+EGCG 100mg/kg (po), and GLY+CM+EGCG 100mg/kg (po). Both doses of EGCG protected against CM-induced renal dysfunction, as measured by serum creatinine and blood urea nitrogen (BUN). In addition, EGCG treatment markedly improved CIN-induced oxidative stress, and resulted in a significant down-regulatory effect on tumor necrosis factor (TNF)-α and nuclear factor (NF)-κB mRNA expression. Moreover, histopathological analysis showed that EGCG also attenuated CM-induced kidney damage. Considering the potential clinical use of CM and the numerous health benefits of EGCG, this study showed the protective role of multi-dose EGCG treatment on CIN and GLY-aggravated CIN through different mechanisms. © 2017 The Author(s).Taylor and Francis Ltd2017Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14920https://doi.org/10.1080/0886022x.2016.12772450886-022XenRenal Failureinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14920