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Efficacy of glycerol and fax seed oil as anti-adhesive barriers after thyroidectomyIdiz, OguzAysan, ErhanFirat, DenizErsoy, Yeliz EmineCengiz, Merve BusraAkbulut, HuseyinIsik, ArdaMuslumanoglu, MahmutGlycerol-therapeutic useLinseed Oil-therapeutic useThyroidectomy-adverse effectsTissue Adhesions-complicationsTissue Adhesions-prevention & ControlAnimalsFemaleFibrosisGlycerolLinseed OilRats, WistarThyroidectomyTissue Adhesionssodium chlorideadhesion barrieranimal experimentanimal tissuearticlecontrolled studydrug efficacygranulomahistopathologynonhumanratscoring systemstaginganimalWistar ratBackground: We evaluated the effects of local fax seed oil and glycerol application for reducing adhesion formation after thyroidectomy. Material/Method: We randomly assigned 18 female Wistar albino rats (median weight: 275 g, median age: 4.5 mth) to 3 groups: 0.1 ml 0.9% NaCl, glycerol, and fax seed oil were sprayed in a perithyroidal area after thyroidectomy operation on all animals as anti-adhesive barriers. Rats were sacrificed on the postoperative 14th day and adhesions were evaluated macroscopically and microscopically. Results: The median macroscopic adhesion score was 3.0±0.0 in the 0.9% NaCl group, 1.33±0.52 in the glycerol group, and 1.67±0.53 in the fax seed oil group. The median histopathological fibrosis scores were 2.33±0.82, 0.67±0.52, and 0.83±0.75, respectively. Both glycerol and flaxseed oil group macroscopic and microscopic scores were significantly lower than the 0.9% NaCl group (p<0.05). There was no significant difference among the groups (p>0.05). Conclusions: Glycerol and fax seed oil both decrease the incidence of post-thyroidectomy adhesion in rats, but glycerol is more effective. © Med Sci Monit, 2014.International Scientific Literature Inc.2014Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/14995https://doi.org/10.12659/msm.8904601234-1010enMedical Science Monitorinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/14995