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oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/150012026-10-18T21:14:24Zopenairedrivercom_ebyu_10000col_ebyu_10001

Metalloproteinases and Their Inhibitors in Patients with Inguinal HerniaIsik, ArdaGursul, CebrailPeker, KemalAydın, MerveFırat, DenizYılmaz, İsmayilAdultCase-Control StudiesFemaleHernia, InguinalHumansHydroxyprolineMaleMatrix Metalloproteinase 1Matrix Metalloproteinase 13Matrix Metalloproteinase 2Matrix Metalloproteinase 9Matrix MetalloproteinasesMiddle AgedProspective StudiesTissue Inhibitor of Metalloproteinase-1Tissue Inhibitor of Metalloproteinase-2Tissue Inhibitor of Metalloproteinase-3Tissue Inhibitor of Metalloproteinasescollagenase 3gelatinase Agelatinase Binterstitial collagenasematrix metalloproteinasetissue inhibitor of metalloproteinasetissue inhibitor of metalloproteinase 1tissue inhibitor of metalloproteinase 2tissue inhibitor of metalloproteinase 3bloodcase control studyhumanAim: The aim of this prospective study is to investigate if there is a relationship between inguinal hernia, matrix metalloproteinases (MMPs), and tissue inhibitors of metalloproteinases (TIMPs). Materials and methods: This case control study was performed on patients admitted to the general surgery department of Erzincan University Hospital. Four groups were created: control, indirect hernia, direct hernia, and bilateral hernia. All groups were comprised of 11 patients. Serum and tissue levels of MMP-1, MMP-2, MMP-9, MMP-13, TIMP-1, TIMP-2, TIMP-3, and hydroxyproline were evaluated. Results: MMPs values were significantly high at hernia groups, especially at bilateral hernia group (p < 0.05), whereas TIMPs values were significantly low at bilateral hernia group (p < 0.05). MMPs values were increasing at hernia groups in an order as control, indirect, direct, and bilateral. TIMPs values were decreasing at hernia groups in an order as control, indirect, direct, and bilateral. Conclusion: Increased levels of MMP-1-2-9-13 and decreased levels of TIMP-1-2-3 may have played role in the formation of inguinal hernia. Hernia is not only a local defect, but a reflection of systemic disease. This is even more significant for bilateral hernias. © 2016, Société Internationale de Chirurgie.Springer New York LLC2017Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/15001https://doi.org/10.1007/s00268-016-3858-60364-2313enWorld Journal of Surgeryinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/15001