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Stromal clues in endometrial carcinoma: Loss of expression of β-catenin, epithelial-mesenchymal transition regulators, and estrogen-progesterone receptorSenol, SerkanSayar, IlyasCeyran, Ayse B.Ibiloglu, IbrahimAkalin, IbrahimFirat, UgurKosemetin, DuyguZerk, Pinar EnginAydin, AbdullahE-cadherinEMTEndometriumSex steroid receptorsβ-Cateninbeta CateninBiomarkers, TumorCadherinsCarcinoma, EndometrioidEndometrial NeoplasmsEpithelial-Mesenchymal TransitionFemaleHumansImmunohistochemistryReceptors, EstrogenReceptors, ProgesteroneStromal CellsTissue Array Analysisestrogen receptorprogesterone receptorsex hormonetranscription factor Slugtranscription factor Snailtranscription factor Twisttranscription factor ZEB1tumor markeruvomorulincadherinCDH1 protein, humanArticleEpithelial-stroma interactions in the endometrium are known to be responsible for physiological functions and emergence of several pathologic lesions. Periglandular stromal cells act on endometrial cells in a paracrine manner through sex hormones. In this study, we immunohistochemically evaluated the expression of epithelial-mesenchymal transition regulators (SNAIL/SLUG, TWIST, ZEB1), adhesion molecules (β-catenin and E-cadhenin), estrogen (ER)-progesterone (PR) receptor and their correlation with each other in 30 benign, 148 hyperplastic (EH), and 101 endometrioid-type endometrial carcinoma (EC) endometria. In the epithelial component, loss of expression in E-cadherin, ER and PR, and overexpression of TWIST and ZEB1 were significantly higher in EC than in EH (P<0.01). In the periglandular stromal component, β-catenin and SNAIL/SLUG expression were significantly higher in normal endometrium and simple without atypical EH compared with complex atypical EH and EC (P<0.01). In addition, periglandular stromal TWIST expression was significantly higher in EH group compared with EC (Po0.05). There was significantly negative correlation between β-catenin and ER, TWIST and ER, and TWIST and PR in hyperplastic and carcinomatous glandular epithelium, whereas there was a significantly positive correlation between β-catenin and SNAIL-SLUG, β-catenin and TWIST, β-catenin and ER, β-catenin and PR, SNAIL-SLUG and ER, SNAILSLUG and PR, TWIST and ER, TWIST and PR, in periglandular/cancer-associated stromal cells (P<0.01). In conclusion, the pattern of positive and negative correlations in the expression of epithelial-mesenchymal transition regulators (SNAIL-SLUG and TWIST), sex hormone receptors (ER and PR), and β-catenin between ECs and hyperplasia, as well as between epithelium and stroma herein, is suggestive of a significant role for these proteins and their underlying molecular processes in the development of endometrial carcinomas. © 2015 International Society of Gynecological Pathologists.Lippincott Williams and Wilkins2016Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/15122https://doi.org/10.1097/pgp.00000000000002330277-1691enInternational Journal of Gynecological Pathologyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/15122