2026-10-19T01:52:42Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/151622026-10-18T21:14:26Zopenairedrivercom_ebyu_10000col_ebyu_10001The effect of metamizole on ischemia/reperfusion injury in the rat ovary: An analysis of biochemistry, molecular gene expression, and histopathologyKumbasar, SerkanSalman, SuleymanAl, RagipOzturk, CengizYarali, OguzhanAlp, HamitAltuner, DurduSuleyman, BahadirGene expressionmetamizolemyeloperoxidaseovaryratAnimalsDipyroneFemaleHumansPeroxidaseRatsRats, WistarReperfusion Injuryanimal experimentanimal modelanimal tissueArticlebiochemistrycell adhesioncell migrationcontrolled studyenzyme activityhistopathologyneutrophilnonhumanovarian tissuepolymerase chain reactionreal time polymerase chain reactionanimaldrug effectsObjectives: In this study, we investigated the effect of metamizole on ischemia/reperfusion (I/R) injury an analysis of biochemistry, molecular gene expression, and histopathology in the rat ovary of female albino Wistar rats. Materials and Methods: Animals were divided into four groups; control group with induced ischemia-reperfusion (IRC), ischemia-reperfusion +100 mg/kg metamizole sodium (MS) (IRM-100), ischemia-reperfusion +200 mg/kg MS (IRM-200), and healthy group applied sham operation (SG). Results: Myeloperoxidase (MPO) activity and gene expression increased significantly in IRC and IRM-100 group rat ovarian tissue compared with the SG group (P < 0.0001). However, MPO activity and gene expression in IRM-200 group ovarian tissue decreased significantly compared with the IRC and IRM-100 groups (P < 0.0001). Histopathologically, pronounced congestion, dilated vessels, hemorrhage, edema, degenerative cells, and neutrophil migration and adhesion to the endothelium were observed in the IRC and IRM-100 group ovarian tissues. A small number of congested dilated vessels, mild congestion, and edema were observed in the IRM-200 group, but no neutrophil migration and adhesion to the endothelium or degenerative cells. Conclusions: At 200 mg/kg dose metamizole prevented ovarian injury induced with I/R. This data show that metamizole can be used in the ovarian I/R injury treatment. © 2016 Indian Journal of Pharmacology Published by Wolters Kluwer - Medknow.Medknow Publications2016Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/15162https://doi.org/10.4103/0253-7613.1745150253-7613enIndian Journal of Pharmacologyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/15162