2026-10-19T01:56:03Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/152022026-10-18T20:43:15Zopenairedrivercom_ebyu_10000col_ebyu_10001Impact of-455G/A polymorphism of the β-fibrinogen gene on platelet aggregation in patients with acute coronary syndromeSevimli, SerdarKarakoyun, SuleymanBakirci, Eftal MuratTopcu, SelimKalkan, KamuranBorekci, AbdurrezzakVançelik, Serhatacute coronary syndromesantiplatelet drugsgene polymorphismsAcute Coronary SyndromeAspirinFemaleFibrinogenGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedPlatelet AggregationPlatelet Aggregation InhibitorsPolymorphism, GeneticRisk AssessmentTiclopidineacetylsalicylic acidclopidogreladultarticlegenetic polymorphismhomozygotehumanmajor clinical studypriority journalthrombocyte aggregationtreatment responseWe aimed to investigate the association of aspirin and/or clopidogrel low response with-455G/A polymorphism of β-fibrinogen in patients with acute coronary syndrome (ACS). We enrolled 114 consecutive patients (mean age 61 ± 7, 31 female [27.2%], 83 male [72.8%]) with a first ACS. The diagnostic criteria for ACS were based on current guidelines. The-455 G/A β-fibrinogen polymorphism genotype distribution in the patient group was determined as the following: 54.4% GG homozygote, 39.5% GA, and 6.1% AA homozygote. Clopidogrel low response was present in 25 (21.9%) patients, aspirin low response in 21 (18.4%) patients, and dual antiplatelet low response in 9 (7.9%) patients. In our study, no difference was observed in terms of the distribution of-455 G/A β-fibrinogen polymorphism between the groups with and without aspirin and/or clopidogrel or dual antiplatelet low response in the patient group who underwent aspirin and clopidogrel treatment for ACS (P >.05). © 2013 The Author(s).SAGE PUBLICATIONS INC2014Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/15202https://doi.org/10.1177/10760296135086011938-2723enClinical and Applied Thrombosis/Hemostasisinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/15202