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The biomolecule, 2-[(2-methoxyl)sulfanyl]-4-(2-methylpropyl)-6-oxo-1,6- dihydropyrimidine-5-carbonitrile: FT-IR, Laser-Raman spectra and DFTSert, YusufEl-Emam, Ali A.Al-Deeb, Omar A.Al-Turkistani, Abdulghafoor A.Ucun, FatihÇirak, ÇaǧriFT-IR spectraLaser-Raman spectraPyrimidine-5- carbonitrileVibrational studyCrystallography, X-RayModels, MolecularNitrilesPyrimidinesQuantum TheorySpectroscopy, Fourier Transform InfraredSpectrum Analysis, RamanOptimizationQuantum chemistrynitrilepyrimidine derivativeExchange-correlation functionsFT-IR spectrumHighest occupied molecular orbitalLowest unoccupied molecular orbitalPotential energy distributionQuantum-chemical methodschemical structurechemistryinfrared spectroscopyRaman spectrometryX ray crystallographyRaman scatteringIn this study, the experimental and theoretical vibrational frequencies of a newly synthesized potential chemotherapeutic agent namely, 2-[(2-methoxyl)sulfanyl]-4-(2-methylpropyl)-6-oxo-1,6-dihydropyrimidine-5- carbonitrile have been investigated. The experimental FT-IR (4000-400 cm -1) and Laser-Raman spectra (4000-100 cm-1) of the molecule in solid phase have been recorded. The theoretical vibrational frequencies and optimized geometric parameters (bond lengths and bond angles) have been calculated by using density functional theory (DFT/B3LYP: Becke, 3-parameter, Lee-Yang-Parr) and M06-2X (the highly parametrized, empirical exchange correlation function) quantum chemical methods with 6-311++G(d,p) basis set by Gaussian 09W software, for the first time. The assignments of the vibrational frequencies have been done by potential energy distribution (PED) analysis by using VEDA 4 software. The theoretical optimized geometric parameters and vibrational frequencies have been found to be in good agreement with the corresponding experimental data, and with the results in the literature. In addition, the highest occupied molecular orbital (HOMO) energy, the lowest unoccupied molecular orbital (LUMO) energy and the other related molecular energy values of the compound have been investigated using the same theoretical calculations. © 2014 Elsevier B.V. All rights reserved.PERGAMON-ELSEVIER SCIENCE LTD2014Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/15322https://doi.org/10.1016/j.saa.2014.01.1401386-1425enSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/15322