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Effect of sumac extract on serum oxidative status, RANKL/OPG system and alveolar bone loss in experimental periodontitis in ratsSağlam, MehmetKöseoğlu, SerhatHatipoğlu, MükerremEsen, Hacı HasanKöksal, EkremAlveolar bone lossOsteoprotegerinPeriodontal diseasesReceptor activator of nuclear factor-kappa B ligandRhusAnimalsAntioxidantsCell CountImmunohistochemistryMaleOsteoblastsOxidantsOxidative StressPeriodontitisPlant ExtractsRandom AllocationRANK LigandRats, WistarReproducibility of Resultsantioxidantosteoclast differentiation factoroxidizing agentplant extractanimalbloodchemistrydrug effectsevaluation studyosteoblastpathologyObjectives: Sumac (Rhus coriaria L.) is widely used spice which has several properties such as antioxidant, anti-inflammatory and antimicrobial. The purpose of this animal study was to evaluate the effects of sumac extract on levels of receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin (OPG) expression, serum oxidative status, and alveolar bone loss in experimental periodontitis. Material and Methods: Twenty-four Wistar rats were separated into three groups: non-ligated (NL, n=8), ligature only (LO, n=8), and ligature and treated with sumac extract (S, n=8) (20 mg/kg per day for 11 days). A 4/0 silk suture was placed around the mandibular right first molars subgingivally; after 11 days, the rats were sacrificed, and alveolar bone loss was histometrically measured. The detection of RANKL and OPG were immunohistochemically performed. Levels of serum total antioxidant status (TAS)/total oxidant status (TOS), and oxidative stress index (OSI) were also analyzed. Results: Alveolar bone loss was significantly greater in the LO group compared to the S and NL groups (p<0.05). The number of inflammatory cell infiltrate (ICI) and osteoclasts in the LO group was significantly higher than that of the NL and S groups (p<0.05). The number of osteoblasts in the LO and S groups was significantly higher than that of the NL group (p<0.05). There were significantly more RANKL-positive cells in the LO group than in the S and NL groups (p<0.05). OPG-positive cells were higher in S group than in LO and NL groups (p<0.05). TOS and OSI levels were significantly reduced in S group compared to LO group (P<0.05) and TAS levels were similar in S and NL group (p>0.05). Conclusions: The present study showed that systemic administration of sumac extract may reduce alveolar bone loss by affecting RANKL/OPG balance, TOS and OSI levels in periodontal disease in rats. © 2015, J Appl Oral Sci. All Rights Reserved.Faculdade de Odontologia de Bauru2015Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/15366https://doi.org/10.1590/1678-7757201402881678-7757enJournal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/15366