2026-10-19T01:56:18Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/153762026-10-18T20:30:11Zopenairedrivercom_ebyu_10000col_ebyu_10001The molecular mechanism involved in the protective effect of etodolac against ovarian injury induced with ischemia/reperfusion in ratsAl, Ragip A.Yapca, Omer E.Dogan, HasanMammadov, RenadAltuner, DurduSuleyman, BahadirCetin, NihalEtodolacIL-1βIschemia/reperfusionRatTNF-αinterleukin 1betamyeloperoxidasesuperoxide dismutasetumor necrosis factor alphaanimal modelanimal tissueArticlecontrolled studyDNA synthesisfemalegene expressionischemianonhumanovarian injuryovary diseasereal time polymerase chain reactionreperfusion injuryThis study investigated the protective effect at the molecular level of etodolac against ovarian injury induced in rats with ischemia/reperfusion (I/R). Rats were divided into four groups. The 25 mg/kg etodolac + ovarian ischemia/reperfusion (EIR 25) and 50 mg/kg etodolac+ovarian ischemia/reperfusion (EIR 50) groups were given etodolac by the oral route 1 h before administration of anesthesia. Two h of ischemia and 2 h of reperfusion were applied to ovarian tissue in all groups (except for (SG) sham operation group) 1 h after etodolac administration. The experimental results showed that etodolac at a dose of 50 mg/kg suppressed MPO (myeloperoxidase), TNF-α, IL-1β gene expression in ovarian tissue with I/R better than at a dose of 25 mg/kg. In addition, etodolac at these doses prevented a decrease in SOD gene expression in ovarian tissue subjected to I/R to a significant extent (p < 0.0001). In conclusion, etodolac can be used in the treatment of I/R-related ovarian injury. © 2015, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.Colegio de Farmaceuticos de la Provincia de Buenos Aires2015Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/153760326-2383enLatin American Journal of Pharmacyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/15376