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Mutagenic assessment of three synthetic pyridine-diaryl ketone derivativesOzkan, HakanGultekin, Demet DemirciSezen, SelmaOzgeris, BunyaminGulluce, MedineTumer, FerhanAmes/SalmonellaE. coli WP2Mutagenicitysynthetic pyridine compoundsEscherichia coliKetonesMicrobial ViabilityMutagenesisMutagenicity TestsMutagensOsmolar ConcentrationPyridinesSalmonella typhimuriumSolventsTurkey4-methoxyphenyl-3-pyridinylmethanoneketonemutagenic agentp-tolyl-3-pyridinylmethanonephenyl-3-pyridinylmethanonepyridine derivativesolvent4 methoxyphenyl 3 pyridinylmethanone4 tolyl 3 pyridinylmethanoneaminoacridineketone derivativenitrosoguanidinephenyl 3 pyridinylmethanoneunclassified drugdrug effectsNowadays, there are increasing numbers of studies about synthetic chemicals according to the supply demands of bioactive chemicals. The current study aims to investigate genotoxic potential of bioactive synthetic pyridine compounds, phenyl-3-pyridinylmethanone (1), p-tolyl-3-pyridinylmethanone (2), and 4-methoxyphenyl-3-pyridinylmethanone (3), using Ames/Salmonella and Escherichia coli WP2 bacterial reversion mutagenicity test systems. The mutant bacterial tester strains sodium azide-sensitive Salmonella typhimurium TA1535, 9-aminoacridine-sensitive S. typhimurium TA1537, and N-methyl-N′-nitro-N-nitrosoguanidine-sensitive E. coli WP2uvrA were used to detect the mutagenic potential of the test compounds. The results indicated that none of the test substances showed significant mutagenic activity on S. typhimurium TA1535, TA1537, and E. coli WP2uvrA bacterial strains up to 1 µg/plate concentrations. © 2012, SAGE Publications. All rights reserved.SAGE PUBLICATIONS INC2015Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/15443https://doi.org/10.1177/07482337134918100748-2337enToxicology and Industrial Healthinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/15443