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A comparative investigation of the analgesic effects of metamizole and paracetamol in ratsInce, IlkerAksoy, MehmetAhiskalioglu, AliComez, MehmetDostbil, AysenurCelik, MineYilmaz, IsmayilMammadov, RenadDogan, HasanBoztok Ozgermen, BasakAltuner, DurduAnalgesiaCarrageenanMetamizolePainParacetamolRatsAcetaminophenAnimalsAnti-Inflammatory Agents, Non-SteroidalCyclooxygenase 2DipyroneDrug Evaluation, PreclinicalGlutathioneMaleOxidative StressPain, PostoperativePeroxidaseRats, Wistarmalonaldehydemyeloperoxidasenonsteroid antiinflammatory agentalgesimeteranalgesic activityanimal experimentanimal modelanimal tissueArticlecontrolled studydrug efficacygene expressionBackground: This study investigated the effects of metamizole and paracetamol on pain and oxidative stress induced by scalpel incision and carrageenan in rats. Materials and methods: Total of 144 rats were divided into groups of 12 animals. Six groups each were used for scalpel incision and carrageenan tests. Pain was inflicted by applying a scalpel incision or carrageenan. Pain-created groups by scalpel incision received metamizole (SIM) or paracetamol (SIP) at doses of 250 or 500 mg/kg. Pain-created groups by carrageenan received metamizole (CAM) or paracetamol (CAP) at doses of 250 or 500 mg/kg. Analgesic activity was determined by Basile Algesimeter. The COX-2 and MPO gene expressions were determined, and malondialdehyde and tGSH were measured in rat paws. Results: In the scalpel incision test, pain was reduced in groups of SIM-250 and SIM-500 in the first hour by 65.2% and 91.3%, respectively, and in the third hour by 51.9% and 77.8%, respectively, compared with the SIC group. In SIP-250 and SIP-500 groups, pain was reduced in the first hour by 43% and 74%, respectively, and by 33.4% and 59.3%, respectively, in the third hour compared with the SIC group. In the carrageenan test, in groups CAM-250 and CAM-500, pain was reduced in the first hour by 72.3% and 86.1%, respectively, and by 65.8% and 71.4%, respectively, in the third hour compared with the CCG group. In groups CAP-250 and CAP-500, pain was reduced in the first hour by 52.8% and 69.4%, respectively, and by 28.6% and 25.8%, respectively, in the third hour compared with the CCG group. Metamizole inhibited COX-2 gene expression at a dose of 500 mg/kg in the carrageenan test. At doses of 250 and 500 mg/kg, metamizole reduced COX-2 and MPO gene expressions and oxidative stress induced by scalpel incision or carrageenan. But both doses of paracetamol were unable to suppress that parameters. Conclusions: Our results show that metamizole is more effective than paracetamol for treating surgical trauma-related pain, inflammation, and oxidative stress and hence may be a preferential drug to paracetamol. © 2015 Informa Healthcare USA, Inc.Informa Healthcare2015Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/15458https://doi.org/10.3109/08941939.2014.9987980894-1939enJournal of Investigative Surgeryinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/15458