2026-10-18T23:16:40Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/request

oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/154752026-10-18T21:14:27Zopenairedrivercom_ebyu_10000col_ebyu_10001

Serum YKL-40/chitinase 3-like protein 1 level is an independent predictor of atherosclerosis development in patients with obstructive sleep apnea syndromeBakirci, Eftal MuratÜnver, EdhemDeʇirmenci, HüsnüKivanç, TülayGünay, MuratHamur, HikmetBüyüklü, MutluCeyhun, GökhanTopal, ErgunÇoban, Taha AbdulkadirCarotid intima-media thicknessCoronary artery diseaseInflammationObstructiveSleep apneaYKL-40AdipokinesAdultAtherosclerosisFemaleHumansLectinsMaleMiddle AgedPolysomnographyProspective StudiesSleep Apnea, Obstructivebiological markerC reactive proteinchitinase 3 like protein 1unclassified drugadipocytokineCHI3L1 protein, humanlectinapnea hypopnea indexarterial wall thicknessArticleB scanblood levelbody massObjective: The inflammatory process plays an important role in the development of cardiovascular complications in patients with obstructive sleep apnea syndrome (OSAS). YKL-40/chitinase 3-like protein 1 is a novel biomarker of systemic inflammation. This study aimed to investigate whether carotid intima-media thickness (CIMT), a useful marker for early atherosclerosis, is associated with serum YKL-40/chitinase 3-like protein 1 levels in patients with normotensive and nondiabetic OSAS. Methods: The study included 40 OSAS patients and 40 age-sex- and body mass index-matched healthy controls. Serum YKL-40 levels were detected by enzyme-linked immunosorbent assay. CIMT was measured by B-mode ultrasound. Results: The patients with OSAS had significantly increased CIMT and higher YKL-40 and high sensitivity C-reactive protein (hsCRP) levels than those of the controls. CIMT was strongly correlated with serum YKL-40 levels (r=0.694, p<0.001), hsCRP (r=0.622, p<0.001), age (r=0.525, p=0.001), and weakly correlated with apnea-hypopnea index (AHI) (r=0.365, p=0.021) and the percentage of recording time spent (PRTS) of oxygen saturation <90% (r=0.488, p=0.001). Moreover, it was detected that serum YKL-40 levels were strongly correlated with AHI (r=0.617, p<0.001), and weakly correlated with SaO2 <90% of PRTS (r=0.394, p=0.012) and hsCRP (r=0.486, p=0.001). In multiple regression analyses, age and serum levels of YKL-40 and hsCRP were found to be independent predictors of CIMT. Conclusion: In patients with OSAS, CIMT was increased. This increase was associated with serum YKL-40 level. Increased serum level of YKL-40 may be an early predictor of atherosclerosis development in patients with OSAS. © 2015 Türk Kardiyoloji Derneʇí.Turkish Society of Cardiology2015Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/15475https://doi.org/10.5543/tkda.2015.568051016-5169enTurk Kardiyoloji Dernegi Arsiviinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/15475