2026-10-18T23:53:48Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/request

oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/155132026-10-18T20:43:15Zopenairedrivercom_ebyu_10000col_ebyu_10001

Sulfapyridine-like benzenesulfonamide derivatives as inhibitors of carbonic anhydrase isoenzymes I, II and VIAlp, CemalettinÖzsoy, ŞeydaAlp, Nurdan AlcanErdem, DeryanurGültekin, Mehmet SerdarKüfrevioǧlu, Ömer IrfanŞentürk, MuratSupuran, Claudiu T.BenzenesulfonamidesCarbonic anhydraseInhibitionBenzenesulfonatesCarbonic Anhydrase ICarbonic Anhydrase IICarbonic Anhydrase InhibitorsCarbonic AnhydrasesElectrophoresis, Polyacrylamide GelEnzyme AssaysErythrocytesHumansKineticsMolecular MimicryMolecular StructureStructure-Activity RelationshipSubstrate SpecificitySulfapyridineSulfonamides4 amino n (pyrimidin 2 yl)benzenesulfonamide4 methylbenzenesulfonamideacetazolamidearomatic aminebenzenesulfonamide derivativecarbonate dehydratasecarbonate dehydratase Icarbonate dehydratase IIcarbonate dehydratase inhibitorcarbonate dehydratase viunclassified drugThe inhibition of two human cytosolic carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I, II and human serum isozyme VI, with a series of tosylited aromatic amine derivatives was investigated. The KI ranges of compounds 1-14 and acetazolamide against hCA I ranged between 1.130 and- 448.2 μM, against hCA II between 0.103 and- 14.3 μM, and against hCA VI ranged between 0.340 and- 42.39 μM. Tosylited aromatic amine derivatives are thus interesting hCA I, II and VI inhibitors, and might be used as leads for generating enzyme inhibitors eventually targeting other isoforms which have not been assayed yet for their interactions with such agents. © 2012 Informa UK, Ltd.TAYLOR & FRANCIS LTD2012Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/15513https://doi.org/10.3109/14756366.2011.6177451475-6374enJournal of Enzyme Inhibition and Medicinal Chemistryinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/15513