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oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/155152026-10-18T20:43:07Zopenairedrivercom_ebyu_10000col_ebyu_10001

Changes in serum obestatin, preptin and ghrelins in patients with Gestational Diabetes MellitusBaykus, YakupGurates, BilginAydin, SuleymanCelik, HusnuKavak, BurcinAksoy, AzizSahin, IbrahimDeniz, RulinGungor, SamiGuzel, Saadet P.Minareci, YagmurGestational Diabetes MellitusGhrelinObestatinPreptinAdultCase-Control StudiesDemographyDiabetes, GestationalFemaleHumansInsulin-Like Growth Factor IIPeptide FragmentsPregnancyalanine aminotransferaseaspartate aminotransferasecreatininegastrointestinal hormoneglucosehemoglobinhemoglobin A1chigh density lipoprotein cholesterollow density lipoprotein cholesterolserum albumintriacylglycerolunclassified drugureavery low density lipoprotein cholesterolacylationalanine aminotransferase blood levelalbumin blood levelObjectives: The present study aims to establish the levels of acylated ghrelin, desacylated ghrelin, obestatin and preptin, during pregnancy and the postpartum period in pregnant women with Gestational Diabetes Mellitus (GDM) and healthy pregnancy women. Design and methods: The study registered 20 pregnant women with GDM and 20 healthy pregnant women. Fasting venous blood samples were collected from all cases between weeks 24 and 28 of pregnancy and after 24. h postpartum. Hormones were analyzed using ELISA method. Results: Serum acylated ghrelin (p:0.001), desacylated ghrelin (p:0.001), obestatin (p:0.006) and preptin (p:0.001) levels were all found statistically higher in both groups during the postpartum period, when compared to the pregnancy period. A positive correlation was established between desacylated ghrelin and acylated ghrelin (p:0.008), desacylated ghrelin and preptin (p:0.012) and preptin and insulin (p:0.039) in the GDM group during pregnancy. Conclusions: The studied hormones (especially desacylated ghrelin and obestatin) are critical in GDM pathophysiology based on the comparison of measure after and before the delivery. © 2011 Elsevier Inc..PERGAMON-ELSEVIER SCIENCE LTD2012Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/15515https://doi.org/10.1016/j.clinbiochem.2011.08.11311873-2933enClinical Biochemistryinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/15515