2026-10-19T01:04:41Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/155632026-10-18T21:14:29Zopenairedrivercom_ebyu_10000col_ebyu_10001Protective effect of curcumin against contrast induced nephropathy in rat kidney: What is happening to oxidative stress, inflammation, autophagy and apoptosis?Buyuklu, M.Mehmet Kandemir, F.Ozkaraca, M.Set, T.Murat Bakirci, E.Topal, E.AngiographyApoptosisAutophagyContrastCurcuminNephropathyAnimalsAnti-Inflammatory AgentsAntioxidantsBiological MarkersContrast MediaCytoprotectionDisease Models, AnimalIopamidolKidneyKidney DiseasesMaleNephritisOxidative StressRats, Wistarcatalasecreatininefurosemideglutathioneglutathione peroxidaseindometaciniomeprolmalonaldehydesuperoxide dismutaseureaBACKGROUND: Currently, the number of imaging and interventional procedures that use contrast agents (CAs) is gradually increasing. Oxidative stress plays a significant role in its pathophysiology. Curcumin (CC) is a natural substance with strong antioxidant efficacy. MATERIALS AND METHODS: In total, 24 male Wistar-albino rats were divided into four groups with seven rats in each group. RESULTS: Biochemical measurements showed a significant increase (p < 0.001) in urea, creatinine and malondialdehyde (MDA) but a significant decrease (p < 0.001) in glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) levels in the contrast-induced nephropathy (CIN) group compared with the control group. The immunohistochemical examination revealed a significant increase in autophagic and apoptotic cell death ratios and in the inflammatory signal (p < 0.05). Compared with the CIN group, a significant improvement in these unfavorable parameters was observed with CC therapy. CONCLUSIONS: The preventive efficacy of CC against an experimental model of CIN has been demonstrated.Verduci Editore2014Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/155631128-3602enEuropean Review for Medical and Pharmacological Sciencesinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/15563