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oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/155732026-10-18T20:41:20Zopenairedrivercom_ebyu_10000col_ebyu_10001

Nesfatin-1 and other hormone alterations in polycystic ovary syndromeDeniz, RulinGurates, BilginAydin, SuleymanCelik, HusnuSahin, IbrahimBaykus, YakupCatak, ZekiyeAksoy, AzizCitil, CihanGungor, SamiFerriman-Gallwey scoresNesfatin-1PCOSAdultBlood GlucoseBody Mass IndexCalcium-Binding ProteinsDNA-Binding ProteinsFemaleHormonesHumansInsulinInsulin ResistanceLipidsNerve Tissue ProteinsPolycystic Ovary SyndromeYoung Adultandrogenestradiolfollitropinglucosegonadotropinhypothalamus hormoneluteinizing hormonenesfatin 1progesteroneprolactinsex hormone binding globulintestosteroneunclassified drugPolycystic ovary syndrome (PCOS) is commonly characterised by obesity, insulin resistance (IR), hyperandrogenemia and hirsutism. Nesfatin-1 a recently discovered hormone, acts upon energy balance, glucose metabolism, obesity and probably gonadal functions. This study was to evaluate the circulating levels of nesfatin-1 in patients with PCOS (n = 30) and in age and body mass index (BMI)-matched controls (n = 30). PCOS patients had significantly lower levels of nesfatin-1 (0.88 ± 0.36 ng/mL) than healthy controls (2.22 ± 1.14 ng/mL). PCOS patients also had higher gonadotropin and androgen plasma concentrations, Ferriman-Gallwey scores, blood glucose levels and a homeostasis model of assessment-IR index (HOMA-IR) index than in healthy women. Correlation tests in PCOS subjects detected a negative correlation between nesfatin-1 levels and BMI, fasting blood glucose, insulin levels and a HOMA-IR index. Lower nesfatin-1 concentration may plays a very important role in the development of PCOS. © 2012 Springer Science+Business Media, LLC.Humana Press Inc.2012Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/15573https://doi.org/10.1007/s12020-012-9638-71355-008XenEndocrineinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/15573