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Acylated and desacylated ghrelin, preptin, leptin, and nesfatin-1 peptide changes related to the body mass indexOzkan, YusufTimurkan, Esra SuayAydin, SuleymanSahin, IbrahimTimurkan, MustafaCitil, CihanKalayci, MehmetYilmaz, MusaAksoy, AzizCatak, ZekiyeBOUND LEPTININSULINOBESITYHORMONEIDENTIFICATIONPREVALENCECELLSEndocrinology & MetabolismThis study examines the levels of acylated and desacylated ghrelin, preptin, leptin, and nesfatin-1 peptide changes related to the body mass index (BMI). The subjects were allocated to 5 groups depending on their BMIs as follows: Group I (BMI <18.5 kg/m2); Group II (BMI 18.5-24.9 kg/m2); Group III (BMI 25-29.9 kg/m2); Group IV (BMI 30-39.9 kg/m2); Group V (BMI >40 kg/m2). Serum acylated and desacylated ghrelin, preptin, and leptin levels were measured by the enzyme-linked immunosorbent assay (ELISA) and nesfatin-1 was measured by the enzyme immunoassay (EIA). Desacylated ghrelin levels showed a gradual and statistically significant drop from Group I to Group V, while preptin and leptin levels exhibited a gradual and significant increase from Group I to Group IV. Serum nesfatin-1 levels gradually, but not significantly, increased from Group I to Group III and showed a significant decrease in Groups IV and V. In conclusion, leptin, preptin, and acylated ghrelin (AG) levels increased with higher BMI, whereas desacylated ghrelin (DAG) decreased and nesfatin-1 showed no clear relationship to BMI. © 2013 Yusuf Ozkan et al.HINDAWI LTD2013Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/15591https://doi.org/10.1155/2013/2360851687-8345enInternational Journal of Endocrinologyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/15591