2026-10-19T01:04:08Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/156342026-10-18T21:14:29Zopenairedrivercom_ebyu_10000col_ebyu_10001Life span effects of Hypericum perforatum extracts on Caenorhabditis elegans under heat stressKiliçgün, HasanGöksen, GüldenAgingCaenorhabditis elegansHypericum perforatumlife spanthermal stresHypericum perforatum extractarticleconcentration responsecontrolled studydrug efficacydrug exposureheat stressheat tolerancelifespannonhumanBackground: The beneficial effects of antioxidants in plants are mainly extrapolated from in vitro studies or short-term dietary supplementation studies. Due to cost and duration, relatively little is known about whether dietary antioxidants are beneficial in whole animals′ life span or not. Materials and Methods: To address this question, under heat stress (35°C), Hypericum perforatum was extracted with petroleum ether and the nematodes Caenorhabditis elegans exposed to three different extract concentrations (1mg/mL, 0.1mg/mL, 0.01mg/mL) of H. perforatum. Results: We report that Hypericum perforatum extracts did not increase life span and slow aging related increase in C. elegans. Moreover, one fraction (1mg/mL) increased declines of C. elegans life span and thermotolerance. Conclusion: Given this mounting evidence for life span role of H. perforatum in the presence of heat stress in vivo, the question whether H. perforatum acts as a prooxidant or an antioxidant in vivo under heat stress arises.WOLTERS KLUWER MEDKNOW PUBLICATIONS2012Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/15634https://doi.org/10.4103/0973-1296.1036660976-4062enPharmacognosy Magazineinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/15634