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Synthesis and asymmetric catalytic activity of (1S,1′S)-4,4′- biquinazoline-based primary aminesCakici, MuratCatir, MustafaKarabuga, SemistanUlukanli, SabriKilic, Hamdullah1,1' (4,4' biquinazoline 2,2' diyl)bis(2 methylpropan 1 amine)1,1' (4,4' biquinazoline 2,2' diyl)bis(2 phenylethanamine)1,1' (4,4' biquinazoline 2,2' diyl)bis(2,2 dimethylpropan 1 amine)1,1' (4,4' biquinazoline 2,2' diyl)diethanaminealcoholaldehydeamineamino acidnickelunclassified drugarticlecatalysischlorinationdeprotection reactionenantiomerpolymerizationpriority journalsynthesisA series of (1S,1′S)-4,4′-biquinazoline-based primary amines were prepared from natural amino acids via a six-step reaction sequence of protection and condensation followed by key synthetic steps including chlorination, nickel(0)-mediated homocoupling, and deprotection. These novel amines were screened for the asymmetric ethylation of aryl aldehydes to yield alcohols with an (S)-configuration with enantiomeric excesses (ee) varying from 2% to 95%. © 2011 Elsevier Ltd. All rights reserved.PERGAMON-ELSEVIER SCIENCE LTD2011Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/15708https://doi.org/10.1016/j.tetasy.2011.01.0091362-511XenTetrahedron Asymmetryinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/15708