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En-bloc pelvic resection with concomitant rectosigmoid colectomy and immediate anastomosis as part of primary cytoreductive surgery for patients with advanced ovarian cancerYildirim, Y.Ertas, I.E.Nayki, U.Ulug, P.Nayki, C.Yilmaz, I.Gultekin, E.Dogan, A.Aykas, A.Ulug, S.Ozdemir, A.Solmaz, U.Cytoreductive surgeryEn-bloc pelvic resectionOvarian cancerPrimary anastomosisRectosigmoid colectomyAdenocarcinomaAdenocarcinoma, Clear CellAdenocarcinoma, MucinousAdultAgedAnastomosis, SurgicalCarcinoma, EndometrioidCohort StudiesColectomyColon, SigmoidDisease-Free SurvivalFemaleHumansHysterectomyKaplan-Meier EstimateLymph Node ExcisionMiddle AgedNeoplasms, Glandular and EpithelialOvarian NeoplasmsOvariectomyPelvic ExenterationPeritoneumProctocolectomy, RestorativeRectumRetrospective StudiesObjective: To assess the authors' experiences in en bloc pelvic resection with concomitant rectosigmoid colectomy and primary anastomosis as a part of primary cytoreductive surgery for patients with advanced ovarian cancer. Materials and Methods: A total of 22 patients with FIGO Stage IIB-IV epithelial ovarian cancer who underwent en bloc pelvic resection with anastomosis were retrospectively reviewed. Data analyses were carried out using SPSS 10.0 and descriptive statistics, Kaplan-Meier survival curves, and Log Rank (Mantel-Cox) test were used for statistical estimations. Results: Median age was 58.8 years. FIGO stage distribution of the patients was; one (4.5%) IIB, three (13.7%) IIC, three (13.7%) IIIA, six (27.3%) IIIB, and nine (40.9%) IIIC. Median peritoneal cancer index (PCI) was 8 (range 5-22) and optimal cytoreduction was achieved in 18 patients (81.8%) of whom 13 (59.1%) had no macroscopic residual disease (complete cytoreduction). There was no perioperative mortality. A total of nine complications occurred in seven (31.8%) patients. Anastomotic leakage was observed in one (4.5%) patient. There was no re-laparotomy. Mean follow-up time was 60 months. There were 15 (68.2%) recurrences of which 12 (80%) presented in extra-pelvic localizations. Mean disease-free survival (DFS) and overall survival (OVS) were estimated as 43.6 and 50.5 months, respectively. Patients with complete cytoreduction had a better DFS (p = 0.006) and OVS (p = 0.003) than those with incomplete cytoreduction. Conclusion: En bloc pelvic resection, as a part of surgical cytoreduction, seems to be a safe and effective procedure in many patients with advanced ovarian cancer if required. Despite relatively high general complication rate, anastomosis-related morbidity of this procedure is low as 0.8%. Nevertheless, surgical plan and perioperative care should be personalized according to medical and surgical conditions of the patient.S.O.G. CANADA Inc.2014Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/15746https://doi.org/10.12892/ejgo247920140392-2936enEuropean Journal of Gynaecological Oncologyinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/15746