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Effects of levosimendan on TNF-alpha, BNP and MMP-1 in patients with heart failure with anemiaBüyüklü, MutluKürüm, Akif TurhanTatlís, ErsanSet, TuranAnemiaBrainFactor-alphaHeart failure/drug therapyMatrix metalloproteinase 1Natriuretic peptideTumor necrosisAgedCardiotonic AgentsChi-Square DistributionFemaleHeart FailureHumansHydrazonesInfusions, IntravenousMaleMiddle AgedNatriuretic Peptide, BrainPyridazinesStatistics, NonparametricTreatment OutcomeTumor Necrosis Factor-alphaamino terminal pro brain natriuretic peptidebeta adrenergic receptor blocking agentfurosemideinterstitial collagenaselevosimendanspironolactonetumor necrosis factor alphaarticleBackground: Levosimendan is known with its two-sided effects of strengthening myofibril contraction without increasing myocardial oxygen demand. Anemia is a deteriorating situation that causes increase of drug dosing in patients with heart failure. Objectives: In this study, we compared the effectiveness of levosimendan treatment in decompensated heart failure patients with or without anemia. Methods: Twenty-three anemic patients having class 3 or 4 heart failure according to New York Heart Association (NYHA) and an ejection fraction of below 35% were included to the study. Another 23 patients with the same cardiac diagnosis but without anemia served as control group. Twenty-four hours levosimendan treatment was added to the traditional heart failure treatment of these patients. Samples were taken to measure serum tumor necrotizing factor alpha (TNF-alpha), aminoterminal pro-brain natriuretic peptide (NT-proBNP) and matrix metalloproteinase-1 (MMP-1) levels before and after the administration. Results: There was no significant difference between serum TNF-alpha and MMP-1 levels before and after the treatment (p>0.05). Although NT-proBNP level decreased in both groups after the treatment this was not statistically significant (p=0.531 and p=0.913 for anemia and control groups respectively). Significant restoration of functional capacity was seen in both groups assessed according to NYHA (p<0.001 and p=0.001 for anemia and control groups respectively). Conclusion: Levosimendan treatment shows similar effects in heart failure patients with anemia to that of patients without anemia. However, the early effect of this treatment on TNF-alpha, NT-proBNP and MMP-1 levels is not evident. It provides significant improvement in functional capacity without influence from anemia.ARQUIVOS BRASILEIROS CARDIOLOGIA2012Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/15795https://doi.org/10.1590/s0066-782x20120050000551678-4170enArquivos Brasileiros de Cardiologiainfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/15795