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Synthesis and biological evaluation of (S)-4-aminoquinazoline alcoholsCakici, MuratCatir, MustafaKarabuga, SemistanKilic, HamdullahUlukanli, SabriGulluce, MedineOrhan, Furkanantimutagenic agentquinazoline derivativearticlechemical modificationchlorinationdrug synthesisEscherichia coligenotoxicitymutagenicitynonhumanpriority journalSalmonella typhimuriumA simple synthetic method for the preparation of enantiomerically pure (S)-4-aminoquinazoline alcohols from (S)-quinazolinone alcohols by key steps including chlorination, nucleophilic ipso substitution, and deacetylation is presented. Mutagenic and antimutagenic properties of the (S)-4-aminoquinazoline alcohols were investigated by using Salmonella typhimurium TA1535, and Escherichia coli WP2uvrA tester strains at 0.01, 0.1, and 1 μg/plate concentrations. (S)-4-aminoquinazoline alcohols were found to be genotoxically safe at the tested concentrations. Among the tested (S)-4-aminoquinazoline alcohols, the best antimutagenic activity was obtained with a methyl derivative at 0.1 μg/plate dose. © 2010 Elsevier Ltd. All rights reserved.PERGAMON-ELSEVIER SCIENCE LTD2010Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/16013https://doi.org/10.1016/j.tetasy.2010.05.0401362-511XenTetrahedron Asymmetryinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/16013