2026-10-19T00:02:53Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/request

oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/165002026-10-18T20:36:22Zopenairedrivercom_ebyu_10000col_ebyu_10001

Loss of E-cadherin expression in recurrent non-invasive urothelial carcinoma of the bladderBalci, Mecdi GurhanTayfur, MahirUrothelial carcinoma of the bladderinvasionE-cadherin expressionCELL-ADHESIONCANCERPROGRESSIONMIGRATIONOncologyPathologyBackground: Bladder cancer is the most common malignancy in the urothelial tract. Invasive cancer has a poor prognosis compared to non-invasive cancer, and identifying the cancer type is useful in determining the most appropriate treatment. In this study, the expression ratios of E-cadherin in non-invasive urothelial carcinoma of the bladder were investigated. The goal of the study was to predict possible invasion in the recurrence of these cases. Material and methods: Seventy-two recurrent non-invasive cases of urothelial carcinoma of the bladder were retrospectively analyzed. An immunohistochemical study of E-cadherin was performed of the baseline tissue sections. An evaluation was carried out of the intensity of membranous staining of E-cadherin and the percentage of cells that stained positive. Results: Invasive cancer was identified in the recurrence material of 14 of the 72 urothelial carcinomas of the bladder that were originally non-invasive based on the baseline samples. The rate of invasion in the recurrence material was significantly higher in cases in which the loss of E-cadherin expression was observed. Conclusion: If E-cadherin expression is negative or weak, close clinical follow-up of patients is necessary, even if the initial diagnosis is non-invasive urothelial carcinoma of the bladder. This is because the rate of invasion in these cases is higher in recurrent cases.E-CENTURY PUBLISHING CORP2018Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/165001936-2625enINTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGYinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/16500