2026-10-19T00:29:05Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/request

oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/169892026-10-18T21:13:07Zopenairedrivercom_ebyu_10000col_ebyu_10001

From aquatic plant to therapeutic prospect: LC-MS/MS-guided phytochemical profiling and in vitro antidiabetic, anticholinesterase and molecular insights into Myriophyllum spicatum L.Civas, AyseGunes, FerhatOzer, Elif BeyzaImad Abdulqader, AmenahAkyuz, BeyzanurYuca, HafizeAydin, BilgeKarakaya, SongulMyriophyllum spicatumvanillic acidAlzheimer's diseasediabetesLC-MS/MSmolecular dockingANTIOXIDANT ACTIVITYDOCKINGChemistry, AppliedChemistry, MedicinalChemistryPharmacology & PharmacyMyriophyllum spicatum L. methanolic extract was examined through integrated biochemical, phytochemical, computational analyses. The extract exhibited strong alpha-glucosidase inhibitory activity with an IC50 value of 198.54 & micro;g/mL, demonstrating markedly higher potency than reference inhibitor acarbose (IC50= 4738.12 & micro;g/mL), while no inhibitory activity was detected against alpha-amylase under tested conditions. In anticholinesterase assays, extract showed acetylcholinesterase inhibition with an IC50 value of 9.70 & micro;g/mL, whereas standard inhibitor donepezil exhibited a significantly stronger activity (IC50= 0.30 & micro;g/mL). No inhibitory effect was observed against butyrylcholinesterase for the extract, while donepezil displayed potent inhibition (IC50= 15.40 & micro;g/mL). Extract showed strong ABTS center dot+ scavenging activity (85.7% at 40 & micro;g/mL) but weak DPPH center dot activity (25.6% at 25 & micro;g/mL), suggesting higher affinity for hydrophilic radicals. High total phenolic, flavonoid and tannin contents correlated with antioxidant potential. LC-MS/MS revealed thirteen phenolics, mainly vanillic acid, gallic acid and cyanidin-3-O-glucoside. Docking studies supported selective alpha-glucosidase binding of vanillic acid.TAYLOR & FRANCIS LTD2026Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/16989https://doi.org/10.1080/14786419.2026.26900741478-6419enNATURAL PRODUCT RESEARCHinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/16989