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oai:ebyu-rdlopen.rawdatalibrary.net:ebyu/170102026-10-18T21:13:25Zopenairedrivercom_ebyu_10000col_ebyu_10001

The role of protein oxidation in the development of diabetic microvascular complicationsMertoglu, CumaSiranli, GulsahCoban, T. AbdulkadirKarakurt, YucelErsoy, AlevtinaOzcicek, AdaletArslan, YusufGok, GamzeErel, OzcanDiabetes mellitusmicrovascular complicationsneuropathyretinopathythiol-disulfideAUTOMATED-ASSAYALBUMINHOMEOSTASISMECHANISMSDISEASEMedicine, General & InternalGeneral & Internal MedicineOBJECTIVE: The role of protein oxidation in the development of diabetic microvascular complications was investigated. METHODS: In total, 266 participants were split into five groups: Group 1; diabetes mellitus for at least 10 years without any complications, Group 2; diabetic nephropathy, Group 3; diabetic neuropathy, Group 4; diabetic retinopathy, and Group 5; control group. Thiol, disulfide, ferroxidase, and ischemia-modified albumin (IMA) levels were analyzed in the serum. RESULTS: Native thiol, total thiol, and native thiol/total thiol were lower in Group 4 than Groups 1, 3, and 5 (p<0.001). However, disulfide/native thiol and disulfide/total thiol were higher in Group 4 than all other groups (p<0.001). IMA was higher in Groups 3 and 4 than all other groups (p<0.001). Ferroxidase was lower in Groups 3 and 4 than Group 2 (p<0.001). CONCLUSION: Thiol-disulfide homeostasis impairment in favor of disulfide may have a function in the progress of diabetic retinopathy. Furthermore, the disruptions of IMA and ferroxidase levels involve in the development of diabetic retinopathy and neuropathy.KARE PUBL2021Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/17010https://doi.org/10.14744/nci.2021.333412148-4902enNORTHERN CLINICS OF ISTANBULinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/17010