2026-10-19T04:52:04Zhttps://ebyu-rdlopen.rawdatalibrary.net/oai/requestoai:ebyu-rdlopen.rawdatalibrary.net:ebyu/170672026-10-18T20:56:43Zopenairedrivercom_ebyu_10000col_ebyu_10001Protective effect of daidzein on ovarian ischemia-reperfusion injury in ratsToktay, ErdemGurbuz, Muhammet AliBal, TugbaOzgul, OzlemErba, ElifUgan, Rustem AnilSell, JaleDaidzeinovaryischemia-reperfusion injuryratISCHEMIA/REPERFUSION INJURYANTIOXIDANT ACTIVITYISOFLAVONESMECHANISMSMETABOLITESEXPRESSIONAPOPTOSISCYTOKINESLIVERMedicine, General & InternalGeneral & Internal MedicinePurpose: In this study, our aim was to investigate the potential effects of strong antioxidant daidzein (DZ) on ovarian ischemia and reperfusion injury. Materials and Methods: A total of 42 female Sprague-Dawley rats were randomly divided into seven groups. For the experimental model, the clamps were removed after 3 hours of ischemia, and blood flow was provided again. Then, reperfusion process was terminated for 3 hours. Daidzein was orally administered to animals at doses of 35 and 70 mg/kg 30 minutes before ischemia (I) and ischemia and reperfusion (I/R) procedures. Results: Severe immunoreactivity of the IL-1 beta, IL-6 and Caspase-3 were detected in I and I/R groups. Moderate immunoreactivity of IL-1 beta, IL-6 and Caspase-3 was detected in I+DZ35 and I/R+DZ35 groups, and slightly positivity was detected in I+DZ70 and I/R+DZ70 groups. The SOD activity level increased in the groups treated with Daidzein, while MDA levels decreased. In addition, hemorrhage areas and inflammatory cell migration decreased in I/R+DZ70 and I/R+DZ35 groups, when compared to I/R group in a dose dependent manner. Conclusion: Daidzein has a strong protective role in the treatment of ovarian ischemia-reperfusion injury and can be used as a therapeutic agent.CUKUROVA UNIV, FAC MEDICINE2022Articlehttps://rdlopen.rawdatalibrary.net/r/ebyu/17067https://doi.org/10.17826/cumj.9932502602-3032enCUKUROVA MEDICAL JOURNALinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://ebyu-rdlopen.rawdatalibrary.net/tr/items/ebyu/17067