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Does the intrathecal propofol have a neuroprotective effect on spinal cord ischemia?

ArticleAçık Erişim

Özet

The neuroprotective effects of propofol have been confirmed. However, it remains unclear whether intrathecal administration of propofol exhibits neuroprotective effects on spinal cord ischemia. At 1 hour prior to spinal cord ischemia, propofol (100 and 300 µg) was intrathecally administered in rats with spinal cord ischemia. Propofol pre-treatment greatly improved rat pathological changes and neurological function deficits at 24 hours after spinal cord ischemia. These results suggest that intrathecal administration of propofol exhibits neuroprotective effects on spinal cord structural and functional damage caused by ischemia. © 2015, Editorial Board of Neural Regeneration Research. All rights reserved.

Anahtar Kelimeler

IschemiaNerve regenerationNeural regenerationNeuroprotectionParaplegiaPre-treatmentPropofolSpinal cordadultanimal experimentanimal tissueArticlecontrolled studyhistopathologymalenonhumanratscoring systemspinal cord ischemia
RDL Kalıcı Bağlantı (PID)
https://rdlopen.rawdatalibrary.net/r/ebyu/15136Resmi atıflarda kullanılan kalıcı adres
DOI
https://doi.org/10.4103/1673-5374.170312Yayıncı resmi DOI adresi
Tam Kayıt
AlanDeğerDil
dc.contributor.authorSahin, Murat
dc.contributor.authorGullu, Huriye
dc.contributor.authorPeker, Kemal
dc.contributor.authorSayar, Ilyas
dc.contributor.authorBinici, Orhan
dc.contributor.authorYildiz, Huseyin
dc.date.accessioned2026-10-18T20:29:55.547407602Z
dc.date.available2026-10-18T20:29:55.547407602Z
dc.date.issued2015
dc.description.abstractThe neuroprotective effects of propofol have been confirmed. However, it remains unclear whether intrathecal administration of propofol exhibits neuroprotective effects on spinal cord ischemia. At 1 hour prior to spinal cord ischemia, propofol (100 and 300 µg) was intrathecally administered in rats with spinal cord ischemia. Propofol pre-treatment greatly improved rat pathological changes and neurological function deficits at 24 hours after spinal cord ischemia. These results suggest that intrathecal administration of propofol exhibits neuroprotective effects on spinal cord structural and functional damage caused by ischemia. © 2015, Editorial Board of Neural Regeneration Research. All rights reserved.
dc.identifier.doi10.4103/1673-5374.170312
dc.identifier.eissn1876-7958
dc.identifier.endpage1829
dc.identifier.issn1673-5374
dc.identifier.issue11
dc.identifier.scopus2-s2.0-84949423934
dc.identifier.startpage1825
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/ebyu/15136
dc.identifier.volume10
dc.identifier.wosWOS:000367332800032
dc.language.isoen
dc.publisherEditorial Board of Neural Regeneration Research
dc.relation.ispartofNeural Regeneration Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIschemia
dc.subjectNerve regeneration
dc.subjectNeural regeneration
dc.subjectNeuroprotection
dc.subjectParaplegia
dc.subjectPre-treatment
dc.subjectPropofol
dc.subjectSpinal cord
dc.subjectadult
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectcontrolled study
dc.subjecthistopathology
dc.subjectmale
dc.subjectnonhuman
dc.subjectrat
dc.subjectscoring system
dc.subjectspinal cord ischemia
dc.titleDoes the intrathecal propofol have a neuroprotective effect on spinal cord ischemia?
dc.typeArticle
dspace.entity.typePublication
rdl.citation.scopus6
rdl.citation.wos5
rdl.oa.statusgold
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)