EFFECT OF LUTEIN ON OXIDANTS AND PROINFLAMMATORY CYTOKINE-RELATED LIVER ISCHEMIA-REPERFUSION INJURY

Lutein has an anti-inflammatory impact on tissues, according to recent research. The goal of our research was to see how lutein affected the biochemical and histological results of ischemia-reperfusion (I/R) intervention on rats' livers. A total of 18 rats were divided into a sham operation group (HG), a liver I/R (KIR) group, or lutein (1mg/kg)+liver I/R (LIR) groups. Biochemical measures and histological exams were done in all three groups after I/R intervention. MDA, NF-κB, TNF-α, IL-1, ALT, and AST levels were significantly higher (p < 0.001) in the KIR group compared to the HG and LIR groups, although tGSH was significantly lower (p < 0.001). The HG group was histopathologically normal. The KIR group had severe degeneration, necrosis, and inflammation in the portal area and parenchyma. The LIR group had mild inflammation in the portal area and parenchyma. The use of lutein might be an alternative treatment for liver damage caused by I/R responses during surgery. © 2022 Polish Pharmaceutical Society. All rights reserved.