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Increased platelet distribution width is associated with ST-segment elevation myocardial infarction and thrombolysis failure

ArticleAçık Erişim

Özet

We investigated 2 hypotheses: (1) a relationship between platelet indices and stable coronary artery disease (CAD) and acute ST-segment elevation myocardial infarction (STEMI) and (2) a relationship between platelet indices on admission and thrombolysis outcomes in patients with STEMI. A total of 260 patients were enrolled. The white blood cell (WBC) and platelet distribution width (PDW) were found to be increased in patients with STEMI (P for both <.001). White blood cell and PDW were independent predictors of acute STEMI. Mean platelet volume (MPV) and PDW were significantly higher in the thrombolysis failure group than in the thrombolysis success group (9.9 ± 1.8 vs 9.2 ± 1.5 fL, P =.021 and 17.7 ± 1.0 vs 16.4 ± 2.1 fL, P <.001, respectively). Mean platelet volume and PDW were independent predictors of thrombolysis failure. Patients with acute STEMI had higher PDW than did patients with stable CAD. In addition, higher PDW and MPV seem to correlate with thrombolysis failure in patients with STEMI. © The Author(s) 2013.

Anahtar Kelimeler

coronary artery diseasefibrinolysismean platelet volumemyocardial infarctionplatelet distribution widththrombolysisAgedAged, 80 and overBlood PlateletsFemaleHumansMaleMiddle AgedPlatelet ActivationThrombolytic Therapyacetylsalicylic acidalteplaseclopidogrelheparintenecteplaseadultangiocardiographyarticleblood clot lysiscontrolled studyfibrinolytic therapyhumanleukocyteloading drug dosemajor clinical study
RDL Kalıcı Bağlantı (PID)
https://rdlopen.rawdatalibrary.net/r/ebyu/15796Resmi atıflarda kullanılan kalıcı adres
DOI
https://doi.org/10.1177/0003319713520068Yayıncı resmi DOI adresi
Tam Kayıt
AlanDeğerDil
dc.contributor.authorCetin, Mustafa
dc.contributor.authorBakirci, Eftal Murat
dc.contributor.authorBaysal, Erkan
dc.contributor.authorTasolar, Hakan
dc.contributor.authorBalli, Mehmet
dc.contributor.authorCakici, Musa
dc.contributor.authorAbus, Sabri
dc.contributor.authorAkturk, Erdal
dc.contributor.authorOzgul, Sami
dc.date.accessioned2026-10-18T20:30:38.712540407Z
dc.date.available2026-10-18T20:30:38.712540407Z
dc.date.issued2014
dc.description.abstractWe investigated 2 hypotheses: (1) a relationship between platelet indices and stable coronary artery disease (CAD) and acute ST-segment elevation myocardial infarction (STEMI) and (2) a relationship between platelet indices on admission and thrombolysis outcomes in patients with STEMI. A total of 260 patients were enrolled. The white blood cell (WBC) and platelet distribution width (PDW) were found to be increased in patients with STEMI (P for both <.001). White blood cell and PDW were independent predictors of acute STEMI. Mean platelet volume (MPV) and PDW were significantly higher in the thrombolysis failure group than in the thrombolysis success group (9.9 ± 1.8 vs 9.2 ± 1.5 fL, P =.021 and 17.7 ± 1.0 vs 16.4 ± 2.1 fL, P <.001, respectively). Mean platelet volume and PDW were independent predictors of thrombolysis failure. Patients with acute STEMI had higher PDW than did patients with stable CAD. In addition, higher PDW and MPV seem to correlate with thrombolysis failure in patients with STEMI. © The Author(s) 2013.
dc.identifier.doi10.1177/0003319713520068
dc.identifier.eissn1940-1574
dc.identifier.endpage743
dc.identifier.issn0003-3197
dc.identifier.issue8
dc.identifier.pmid24526792
dc.identifier.scopus2-s2.0-84905908759
dc.identifier.startpage737
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/ebyu/15796
dc.identifier.volume65
dc.identifier.wosWOS:000340715700013
dc.language.isoen
dc.publisherSAGE Publications Inc.
dc.relation.ispartofAngiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcoronary artery disease
dc.subjectfibrinolysis
dc.subjectmean platelet volume
dc.subjectmyocardial infarction
dc.subjectplatelet distribution width
dc.subjectthrombolysis
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectBlood Platelets
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPlatelet Activation
dc.subjectThrombolytic Therapy
dc.subjectacetylsalicylic acid
dc.subjectalteplase
dc.subjectclopidogrel
dc.subjectheparin
dc.subjecttenecteplase
dc.subjectadult
dc.subjectangiocardiography
dc.subjectarticle
dc.subjectblood clot lysis
dc.subjectcontrolled study
dc.subjectfibrinolytic therapy
dc.subjecthuman
dc.subjectleukocyte
dc.subjectloading drug dose
dc.subjectmajor clinical study
dc.titleIncreased platelet distribution width is associated with ST-segment elevation myocardial infarction and thrombolysis failure
dc.typeArticle
dspace.entity.typePublication
rdl.citation.scopus60
rdl.citation.wos56
rdl.departmentDepartment of Cardiology, School of Medicine, Erzincan University, Erzincan, Turkey.
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.source.indexPUBMED
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)