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11 →- ArticleYayıncıda açık erişim2026Gingival inflammation and plaque accumulation affect therapeutic outcomes in patients with acne vulgaris
Okumuş, Ömer Faruk; Yazıcı, Mustafa; Kantarci, Alpdoğan
Background: We hypothesized that acne vulgaris (AV) and gingivitis were associated through systemic inflammatory mechanisms, sharing common etiological factors. This study aimed to identify the association between AV and gingivitis and to assess changes in acne severity in relation to changes in the plaque index (PI). Methods: This prospective, observational study included 150 patients aged 13 to 19 years, divided into three equal groups based on acne severity. The PI and the gingival index (GI) of all participants were recorded, followed by oral hygiene instruction and scaling. The severe acne group was re-evaluated after 1.5 months, constituting the follow-up stage of the study. These patients were then divided into two subgroups based on the degree of change in their acne scores. Changes in PI and GI were calculated from repeated measurements. Results: At baseline, although no significant difference was observed between the groups in terms of PI scores (p > 0.05), the GI scores were significantly higher in the severe acne group compared with the mild acne group (p < 0.001). At the re-evaluation, the subgroup with more pronounced improvement in acne scores showed significantly greater changes in both GI and PI values (p < 0.001), and the magnitude of these changes demonstrated good discriminative performance for acne improvement (AUCs = 0.896–0.903; p < 0.001). Conclusions: The findings suggested that gingival inflammation was associated with the severity of AV lesions, independent of plaque accumulation. Thus, improvements in gingival inflammation and plaque accumulation were associated with AV-associated symptom improvement. Trial registration: This study was registered in ClinicalTrials.gov under the number NCT06237387 on May 24, 2024. Plain language summary: Acne vulgaris and gingivitis are common inflammatory diseases. Etiological factors such as nutrition, hormonal changes associated with puberty, and hygiene habits are effective in both diseases. This study aimed to examine the relationships among plaque accumulation, gingivitis, and acne vulgaris. A total of 150 adolescents were included in the study, and participants were divided into three groups based on acne severity: mild, moderate, and severe. All participants were assessed for plaque and gingival inflammation, and all received oral hygiene instruction and dental scaling. Greater reductions in plaque levels and gingival inflammation were observed in patients who showed more pronounced regression of acne lesions.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2025A new HLA susceptibility haplotype defined in three familial cases of frontal fibrosing alopecia; [Üç ailevi frontal fibrozan alopesi vakasında tanımlanan yeni bir HLA duyarlılık haplotipi]
Özdemir, Ahmet Kağan; Hayran, Yıldız; Özmen, Füsun; Korkut, Melek Günindi; Çakmak, Seray Külcü
Frontal fibrosing alopecia (FFA) is a scarring alopecia that primarily affects postmenopausal women. Although its etiology remains unknown, familial cases suggest a genetic basis. In this case report, we present the findings of three sisters with familial FFA, aged 55, 60, and 62 years, from Türkiye. Genetic analysis revealed that all three sisters shared the human leukocyte antigen (HLA)-A*11:01; B*35:01; C*04:01 haplotypes. Two sisters had HLA-DRB1*03:01 and HLA-DQB1*02:01, while the third had HLA-DRB1*01:01; HLA-DQB1*05:01. The shared HLA-A*11:01, B*35:01, and C*04:01 haplotype has not been previously associated with familial FFA. This finding marks the first familial FFA report from Türkiye and suggests a new genetic susceptibility haplotype for FFA in the Turkish population. The variation in HLA-DRB1 and HLADQB1 alleles among the sisters indicates complex genetic influences on the familial FFA. Further research is required to determine the role of these genetic variations in disease progression and to identify potential therapeutic approaches.
RDL Kalıcı Kaydıİncele - ArticleYayıncıda açık erişim2025Changes of plasma amino acid levels and metabolic pathways in isotretinoin therapy: ınsights into managing acne vulgaris side effects
Akman, Tugrul Cagri; Yazıcı, Mustafa; Atila, Alptug
Acne vulgaris can be effectively treated with isotretinoin, however, there are several side effects both during and after the treatment. Preventing these side effects is important for continued treatment. This study focused on the relationship between the changes in the levels of plasma amino acids of patients with acne vulgaris after three months of isotretinoin treatment and the side effects. A pre- and post-treatment plasma sample of 35 patients was collected. Samples were analyzed by liquid chromatography-tandem mass spectrometry. After treatment, the plasma levels of 15 amino acids changed statistically. While L-arginine, taurine, L-asparagine, and L-proline levels decreased, L-serine, L-alanine, and L-cystine levels also increased. (p < 0.05) When the amino acid profiles of male and female patients before and after treatment were compared, the plasma levels of L-arginine (p = 0.0017), L-cystine (p = 0.0224) and L-histidine (p = 0.0167) were statistically different. Additionally, the correlation matrix analysis revealed a strong correlation (R > 0.8) between L-leucine, L-isoleucine, L-norvaline, and L-valine. The effect of isotretinoin treatment on eighteen metabolic pathways such as cysteine and methionine metabolism, glycine, serine and threonine metabolism, alanine, aspartate and glutamate metabolism, arginine and proline metabolism is strongly related to the treatment of therapeutic and side effects of isotretinoin. According to the results of the study, the use of L-arginine, L-asparagine, N-acetylcysteine and taurine supplements during isotretinoin treatment may help avoid side effects of skin dryness, blepharitis, nail fragility, and fatigue. As a result, the study provided useful information for enhancing the safety and efficacy of isotretinoin treatment, as well as lowering isotretinoin-related side effects.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2024Human Demodex mites (Acari: Demodicidae) as a possible etiological factor in Rosacea: A cross-sectional study from Turkey
Zeytun, Erhan; Yazici, Mustafa
This study was conducted to determine the prevalence and burden of Demodex mites in patients with rosacea, and to investigate their potential contribution to the aetiology of rosacea. The study included 82 patients (44 with papulopustular rosacea and 38 with erythematotelangiectatic rosacea) diagnosed with rosacea by clinical examination and 82 healthy controls without dermatologic disease. Samples were obtained from each participant from the cheek, nasolabial, and chin regions using standardised skin surface biopsy (SSSB). Samples were examined under a light microscope, and Demodex species were identified and counted. Demodex positivity (≥5 mites) was detected in 91% of patients and 20% of controls in the study (p< 0.01). Only D. folliculorum (total 1328, mean 44.27/cm2) was detected in 37% of patients and D. folliculorum + D. brevis coinfection (total 6071, mean 134.91/cm2) in 55% of patients. Only D. folliculorum (total 97, mean 6.06/cm2) was detected in 20% of healthy controls, while D. folliculorum + D. brevis co-infection was not detected. The study showed that Demodex burden in patients with rosacea was approximately 30 times higher than in healthy controls and was caused by coinfection of D. folliculorum and D. brevis (mean Demodex burden: 179.18/cm2 in patients, 6.06/ cm2 in healthy controls). It was concluded that Demodex infestation, especially co-infection with D. folliculorum and D. brevis, may be a potential factor in the aetiology of rosacea that should not be ignored in the clinic, and that it may be appropriate to initiate antiparasitic treatment when the parasite is detected.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2024Analysis of Isotretinoin-Induced Alterations in the Levels of Plasma Trace Elements: Investigation of the Relationship Between Magnesium, Phosphorus, Potassium, Zinc, and Treatment-Related Side Effects
Akman, Tugrul Cagri; Yazici, Mustafa; Atila, Alptug; Mertoglu, Cuma
Isotretinoin is an effective treatment against acne vulgaris, but it also causes many side effects during and after the treatment. The relationship between the changes in the levels of plasma trace elements of patients with AV after 3 months of isotretinoin treatment and the side effects was investigated in the study. Plasma samples of 35 patients were collected before and after isotretinoin treatment. Samples were analyzed by Inductively Coupled Plasma–Mass Spectrometer. After treatment, the levels of phosphorus, magnesium, and zinc in plasma increased statistically, while the level of potassium decreased (p < 0.05). The treatment had differing effects on zinc levels based on the gender of the individuals. With treatment, the levels of zinc in the plasma of men showed a greater increase compared to women (p = 7.3e-04). Additionally, the correlation matrix analysis revealed a strong correlation (R > 0.8) between magnesium and calcium. According to the study results, the change in phosphorus and potassium levels shows that isotretinoin affects kidney functions. The results suggest that phosphorus, potassium, magnesium, and zinc are associated with fatigue, dry skin and chapped lips, hair loss, and sebum secretion, respectively. Consequently, the study emphasizes the need for a comprehensive pre-treatment assessment, including monitoring of liver and kidney function as well as the levels of phosphorus and potassium in patients.
RDL Kalıcı Kaydıİncele - ArticleYayıncıda açık erişim2022Prevalence and density of Demodex mites (Acari: Demodecidae) in patients with seborrheic dermatitis
Zeytun, Erhan; Yazıcı, Mustafa
This study was conducted to determine the prevalence and density of Demodex mites in patients with seborrheic dermatitis. The study included 37 patients and 35 healthy controls who were diagnosed with seborrheic dermatitis by clinical examination. The sample materials were taken from the cheek, nasolabial and jaw areas of the participants using the standard superficial skin biopsy method and examined for the presence and number of Demodex mites under light microscopy. Demodex spp. mites were detected in 34 (91.9%) of the patients and in 20 (60%) of the controls. Demodex folliculorum was detected in 34 of 37 patients (mean 15.7/cm2; total 535) and D. brevis (mean 0.6/cm2; 20 total) in six patients. Demodex folliculorum was detected in 20 of 35 healthy controls (mean 2.7/cm2; total 56) and D. brevis (mean 0.5/cm2; total 1) in one of the 35 healthy controls. When patients and controls were compared in terms of Demodex prevalence and density, the differences were statistically significant. In conclusion, Demodex mites are more prevalent in patients with seborrheic dermatitis in Erzincan Province of Turkey. This condition may be related to the amount of sebum in patients with seborrheic dermatitis, however, this issue should be supported by further studies in which sebum levels are measured and ilarger number of patients are involved.
RDL Kalıcı Kaydıİncele - ArticleYayıncıda açık erişim2021Effect of the varicella vaccination implementation on the development of herpes zoster in children and adolescents
Inan Yuksel, Esma; Kara Polat, Asude; Gore Karaali, Muge; Koku Aksu, Ayse Esra; Gurel, Mehmet Salih
Herpes zoster (HZ) is an infectious disease caused by latent varicella-zoster virus reactivation. There are conflicting reports on the varicella vaccine's effect on the incidence of HZ in children and adolescents. This study aimed to determine the impact of the single dose of varicella vaccination on HZ prevalence during childhood and adolescence. The study included children and adolescents aged <18 years who presented to the dermatology outpatient clinic between 2005 and 2019 and were diagnosed with HZ. Considering that the universal vaccination program started to be implemented in Turkey in 2013, non-vaccinated cases in the prevaccination period, vaccinated cases in the postvaccination period, and non-vaccinated patients in the postvaccination period were compared in terms of HZ prevalence and demographic features. After the initiation of the varicella vaccination program, the prevalence of HZ was found to decrease by 24.7% in all. The HZ prevalence was significantly reduced in vaccinated children, while the rate of decrease in non-vaccinated children was low (58.6% and 16.4%, respectively). The median age of the non-vaccinated cases in the postvaccination period (10 [min 0.5-max 17] years) was significantly higher compared to the other groups (p < 0.001). The number of cases aged <2 years was the highest in the vaccinated group (p < 0.001). Administration of a single dose of varicella vaccine was insufficient to decrease the prevalence of HZ <18 years of age. In the post-vaccination period, the frequency of HZ in unvaccinated cases increased in adolescence. In vaccinated children, HZ seems to develop at an earlier age.
RDL Kalıcı Kaydıİncele - ArticleYayıncıda açık erişim2019Incidence and density of Demodex folliculorum and Demodex brevis (Acari: Demodicidae) in patients with acne in the province of Erzincan, Turkey
Zeytun, Erhan; Yazıcı, Mustafa
The present study was carried out to determine the incidence and density of Demodex folliculorum (Simon, 1842) and Demodex brevis Akbulutova, 1963 in patients with acne. The study included 210 patients diagnosed with acne during clinical examination, and 150 healthy controls without any facial dermatoses. In the study, samples were taken from the right cheek, left cheek, nasolabial area, and chin of the participants using the Standard Superficial Skin Biopsy technique. Samples were examined under a light microscope, and Demodex species were identified and counted. Demodex positivity (≥5 mites) was detected in 62.4% of the patients and 16.7% of the controls in the study (p < 0.001). A total of 3325 (mean: 25.4/cm 2 ) mites were isolated from Demodex-positive patients. A total of 2015 (mean: 19.2/cm 2 ) mites were isolated from patients infested with D. folliculorum only, 52 (mean: 7.4/cm 2 ) mites were isolated from patients infested with D. brevis only, and 1058 (mean: 65.2/cm 2 ) mites were isolated from patients infested with both species. The mean density of both mites (co-infection D. folliculorum and D. brevis) was detected as 21.0, 43.5, and 117.1/cm 2 respectively, in patients with mild, moderate, and severe acne. In the controls who was Demodex positive, only D. folliculorum or co-infection with both mites were detected, not D. brevis alone. A total of 167 (mean: 6.7/cm 2 ) mites were isolated from these controls. As a result, Demodex mites were found to be very common and intense in patients with acne in Erzincan, Turkey. It was also concluded that there was a positive correlation between Demodex mites and degree of acne, and that the co-infection of D. folliculorum and D. brevis aggravated the clinical picture in patients with acne. It may be helpful to consider these findings in clinical assessments of patients with acne.
RDL Kalıcı Kaydıİncele - ArticleYayıncıda açık erişim2019Molecular characterization and subtyping of Blastocystis in urticarial patients in Turkey
Aydin, Merve; Yazici, Mustafa; Demirkazik, Mehtap; Koltas, Ismail; Cikman, Aytekin; Gulhan, Baris; Duran, Tugce; Yilmaz, Aysun; Kara, Murat
Objective: To investigate Blastocystis' etiologic role and association with gastrointestinal symptomatology in acute and chronic urticaria patients and to identify Blastocystis subtypes responsible for urticaria. Methods: The study included urticaria patients and healthy individuals that presented to our polyclinic between June 2015 and May 2017. The participants were assigned into Group I (137 patients), subdivided into acute (72) and chronic urticaria patients (65), and Group ? (129 control individuals). Blastocystis presence was investigated by native-Lugol examination, trichrome staining, PCR using sequence tagged site primers, and DNA sequencing analysis. The phylogenetic tree was constructed. Results: The native-Lugol and trichrome staining methods revealed that 16 patients (16/133, 12.0%) had Blastocystis-positive stool samples, of which seven samples (7/133, 5.3%) belonged acute and nine (9/133, 6.8%) to chronic urticaria patients. Concerning Blastocystis subtypes, of the acute urticaria patients, three had subtype 1 (ST1), one had ST2, and three had ST3. Of the chronic urticaria patients, one had ST1 and eight had ST3. Blastocystis positivity was detected in two control individuals (2/123, 1.6%), both being ST3. All subtypes identified by PCR were confirmed by the sequencing analysis. The acute and chronic urticaria groups showed no statistically significant differences for Blastocystis positivity (P=0.60) and subtype distribution (P=0.15). A statistically significant difference was found between the urticaria patients and the controls for Blastocystis positivity (P<0.01), but not for subtype distribution (P=0.67) or for Blastocystis presence and gastrointestinal complaints. Conclusions: This study on Blastocystis subtype distribution among Turkish urticaria patients showed results consistent with the literature. It was concluded that Blastocystis should be kept in mind in patients with urticaria.
RDL Kalıcı Kaydıİncele - EditorialYayıncıda açık erişim2015Spontaneous Milk Fistula from an Accessory Breast: An Extremely Rare Case
Firat, Deniz; Idiz, Oguz; Isik, Arda; Peker, Kemal; Atar, Nilgun; Gul, Eylem
RDL Kalıcı Kaydıİncele
Tam Kayıt
| Alan | Değer | Dil |
|---|---|---|
| dc.date.accessioned | 2026-10-20T15:26:04.439870041Z | |
| dc.date.available | 2026-10-20T15:26:04.439870041Z | |
| dc.identifier.uri | https://rdlopen.rawdatalibrary.net/r/ebyu/22870 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.title | Deri ve Zührevi Hastalıkları Anabilim Dalı | tr |
| dc.title | Department of Dermatology | en |
| dspace.entity.type | OrgUnit | |
| organization.identifier.code | tip-dermatoloji | |
| organization.unitType | department | |
| rdl.unit.alias | dermatol |