Araştırmacılar(1)

• Koseturk, Merve

• ArticleYayıncıda açık erişim2025/r/ebyu/11780
  Protective effect of adenosine triphosphate against cisplatin-induced necrotic and degenerative oral mucositis in rats

  Salcan, Ismail; Dilber, Muhammed; Suleyman, Zeynep; Yucel, Nurinisa; Salcan, Sara; Kesan, Sefa; Yazici, Gulce Naz; Celik, Fatih; Koseturk, Merve; Alp, Nurdan Alcan

  Inflammation, oxidative damage, and adenosine triphosphate (ATP) depletion play a role in the7 pathogenesis of cisplatin (CIS)-induced oral mucositis. Objective: The purpose of this research is to examine8 the impact of ATP against potential oral mucositis development in cisplatin-treated rats. Methodology All rats9 were randomly assigned to four groups, namely healthy control group (HG), ATP group (ATPG), Cisplatin10 group (CISG), and ATP + Cisplatin group (ATCS). Firstly, ATP 4 mg/kg was administered via intraperitoneal11 injection (IP) to both ATPG and ATCS groups. The same volume of normal saline was injected into HG and12 CISG groups. After 1 h, cisplatin 5 mg/kg was administered via IP to CISG and ATCS groups. The drugs13 were taken 1x1 for 7 d. Later, tongue tissues were collected from all groups. Biochemical, macroscopic,14 and histopathological examinations were performed on all tissues. Results: ATP inhibited cisplatin-induced15 oxidative damage and pro-inflammatory cytokines levels in tongue tissue. In the CIS group, a significant16 number of distinct sulcus formations were found in the apex and corpus, as well as a few ulcer foci in the17 corpus, significant papilla loss, and bleeding. Meanwhile, in the ATP group, a similar appearance to healthy18 tissue was observed. Histopathologically, it was determined that in cisplatin-aggravated tongue tissue19 damage, filiform papillae decreased when ATP was administered, and the arrangement and structures of20 the epithelium, blood capillaries, muscle groups, and adipose cell groups were normal. Conclusions: Oral21 mucositis caused by cisplatin is alleviated by ATP. These findings may be useful for developing new therapeutic22 approaches to prevent or treat mucositis, a side effect so severe that can lead to treatment discontinuation.23 24.

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• ArticleYayıncıda açık erişim2023/r/ebyu/19926
  Impact of the Coronavirus Disease 2019 Pandemic on Patient Applications at the Endodontic Clinic

  Bayram, Emre; Koseturk, Merve

  Objective: The pandemic that occurred in 2019 as a result of a virus’s appearance has altered every aspect of life. This virus, known as severe acute respiratory syndrome novel coronavirus 2 and affecting the respiratory system, is spread through inhalation, saliva, aerosol, and contaminated places like other viruses of a similar nature. Dentistry has also been affected by the elevated danger of contamination during dental procedures. This study aims to evaluate how the coronavirus disease 2019 epidemic has affected patient applications at the endodontic clinic. Our work is believed to assist researchers and doctors in figuring out and assessing the number of patients and required treatments at times when the need for urgent care surges. Methods: The coronavirus disease 2019 pandemic’s impact on patients who applied to the endodontic clinic was examined in this retrospective observational study. This study compared patient applications from the year before the epidemic (March 2019-March 2020) with those from the first year of the pandemic (2020-2021). Age, gender, and chronic illnesses variations in the applications were assessed. Furthermore, the impact of the number of coronavirus disease 2019 cases discovered in Türkiye on the number of patients seeking treatment at the clinic during the pandemic was assessed. Results: In the year after the pandemic, there were 7337 patient admissions, a decrease of 69.7% from the year before the outbreak. Despite the absence of a statistically significant gender-based variation, the 45-64 age category had fewer respondents than the other age groups. According to the findings, there was no statistically significant correlation between the number of cases recorded in Türkiye and the number of patient admissions. Conclusion: According to our data, those who applied during the pandemic had lower average ages, genders, and comorbid diseases than those who applied before the pandemic. The number of patients accessing the clinic during times of restrictions decreased.

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