Gökten, Murat; Zırh, Selim; Sezer, Can; Bahador Zırh, Elham; Bulut Gökten, Dilara

The original version of this article, published on 11 April 2024, unfortunately contained a mistake. The following Authors and their affiliations were missing from the author list. Selim Zırh Department of Histology, Binali Yıldırım University, Erzincan, Turkey Can Sezer Department of Neurosurgery, University of Health Sciences, Adana City Training and Research Hospital, Adana, Turkey Elham Bahador Zirh Department of Histology, TOBB University of Economics and Technology, Ankara, Turkey Dilara Bulut Gökten Department of Internal Medicine-Rheumatology, Tekirdag Namik Kemal University, Tekirdag, Turkey The publisher apologizes for the error. The original article has been corrected.

Gökten, Murat; Zırh, Selim; Sezer, Can; Zırh, Elham Bahador; Gökten, Dilara Bulut

Background: Traumatic spinal cord injury (SCI) is the most common preventable cause of morbidity. Despite rapid advances in medicine, effective pharmacological treatment against SCI has not yet been confirmed. This study aimed to investigate the possible anti-inflammatory, antiapoptotic, and neuroprotective effects of safinamide after SCI in a rat model. Methods: A total of 40 male Wistar albino rats were randomly divided into four groups. Group 1 underwent only laminectomy. Group 2 underwent SCI after laminectomy. In group 3, SCI was performed after laminectomy, and immediately afterward, intraperitoneal physiological saline solution was administered. In group 4, SCI was performed after laminectomy, and 90 mg/kg of safinamide was given intraperitoneally immediately afterward. Moderate spinal cord damage was induced at the level of thoracic vertebra nine (T9). Neuromotor function tests were performed and levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β) were measured. In both serum and spinal cord tissue, immunohistochemistry and histopathology studies were also conducted. Results: TNF-α, IL-1β, and IL-6 levels were found to be significantly increased in group 2 and group 3. In group 4, these levels were statistically significantly decreased. Group 4 also exhibited significant improvement in neuromotor function tests compared to the other groups. Histopathologically, it was found that group 4 showed significantly reduced inflammation and apoptosis compared to the other groups. Conclusion: This study revealed that safinamide has neuroprotective effects against SCI due to its anti-inflammatory, antiapoptotic, and antioxidant activities.

Ozoner, Baris; Kilic, Mustafa; Aydin, Levent; Aydin, Seckin; Arslan, Yusuf Kemal; Musluman, Ahmet Murat; Yilmaz, Adem

Background: Post-traumatic hydrocephalus (PTH) is one of the primary complications during the course of traumatic brain injury (TBI). The aim of this study was to define factors associated with the development of PTH in patients who underwent unilateral decompressive craniectomy (DC) for TBI. Methods: A total of 126 patients, who met the inclusion criteria of the study, were divided into two groups: patients with PTH (n = 25) and patients without PTH (n = 101). Their demographic, clinical, radiological, operative, and postoperative factors, which may be associated with the development of PTH, were compared. Results: Multivariate logistic regression analysis revealed that cranioplasty performed later than 2 months following DC was significantly associated with the requirement for ventriculoperitoneal shunting due to PTH (p < 0.001). Also, a significant unfavorable outcome rate was observed in patients with PTH at 1-year follow-up according to the Glasgow Outcome Scale-Extended (p = 0.047). Conclusions: Our results show that early cranioplasty within 2 months after DC was associated with a lower rate of PTH development after TBI.