Yıldırım, Sümeyra Tuna

Schiff bases and their metal complexes, which play a role in various biological processes, are one of the most important classes of organic and inorganic compounds. Due to their high use in the field of health, it is important to introduce these compounds into the literature through synthesis and research studies. In this study a new Schiff base ligand was synthesized by the reaction of 4-diethylamino-2-hyrdoxybenzaldehyde with o-aminophenol. This ligand was used to prepare Co(II), Ni(II), Cu(II) and Zn(II) complexes. The structural characterization of the synthesized ligand and metal complexes was elucidated by various spectroscopic and thermal analysis methods such as FT-IR,1 H-NMR,13 C-NMR, UV-Vis., XRD, SEM and TGA. As a result of these characterization studies, it was determined that the synthesized Schiff base acted as an N2O2 type tetradentate ligand and that the metal ions were bound to the ligand via phenolic oxygen and azomethine nitrogen.

Akman, Tugrul Cagri; Kadioglu, Yucel; Bayrak, Burak; Yildirgan, Mehmet İlhan; Disci, Esra

The effect of total gastrectomy (TG) on plasma free amino acid (PFAA) concentrations in patients with stage II gastric cancer was investigated in the study. Nineteen patients' plasma samples were collected before and three months post-gastrectomy, and PFAA levels were quantified using LC-MS/MS. For gradient elution of amino acids, the mobile phases (A: 3% formic acid-5% methanol-30 mM ammonium formate, B: acetonitrile) and a Hypersil C18 column (100 mm x 2.1 m, 1.9 µm) were used. The findings revealed substantial modifications in the profile of PFAA after TG. In particular, the concentrations of twenty amino acids increased significantly, including branched-chain amino acids, L-glutamate, L-alanine, L-methionine, glycine, L-cystine, and L-histidine. Conversely, L-arginine was also reduced statistically. These alterations in the PFAA profile indicate the favorable effects of TG on various physiological processes, such as enhanced immune function, improved tissue healing, and increased energy production. Investigating the effects of various surgical techniques on PFAA profiles is a promising approach for optimizing surgical procedures, improving metabolic function, increasing immunological responses, and improving overall quality of life. These findings highlight the significance of evaluating amino acid metabolism as an important part of treatment, given its potential to improve clinical outcomes and general well-being.

Burmaoglu, Serdar

The first total syntheses of Balsacone C (16) and Balsacone B (17), mainly based on a convergent strategy, were described. The crucial step of this strategy was the alkylation of trihydroxydihydrochalcone derivatives 7 and 8 with cinnamyl bromide derivative 13. For this, compounds 7 and 8 were prepared starting from trihydroxyacetophenone (1) in four steps. Then compound 13 was prepared starting from coumaric acid (9) in four steps