Rembielak, Agata; Yau, Thomas; Akagunduz, Baran; Aspeslagh, Sandrine; Colloca, Giuseppe; Conway, Aoife; Danwata, Falalu; del Marmol, Veronique; O'Shea, Chuck; Verhaert, Marthe

Introduction: Non-melanoma skin cancer (NMSC) is becoming ever more prevalent among older adults. However, older adults with NMSC are often underrepresented in clinical trials and guidelines on effective management is still unclear. The International Society of Geriatric Oncology (SIOG) created a multi-disciplinary task force to explore the potential in developing practical guidelines for the treatment of older patients with basal cell carcinoma (BCC) and skin (cutaneous) squamous cell carcinoma (cSCC). Materials and Methods: A systematic literature search to identify relevant and up-to-date literature on treatment of NMSC in older adults was conducted on various databases including MEDLINE, Embase, CINAHL, Cochrane, and PubMed. The resulting papers were discussed by an expert panel, leading to a consensus recommendation. Results: A total of 154 articles were identified for the expert panel to utilise in generating consensus recommendations. A major focus on geriatric assessment and management options including surgery, radiotherapy, systemic therapy, clinical monitoring, and medical/medicophysical therapy were reviewed for recommendations. Discussion: Patient age should not be the sole deciding factor in the management of patients with NMSC. Assessment from a multidisciplinary team (MDT) is crucial, and the decision-making process should consider the patient's lifestyle, needs, and expectations. A comprehensive geriatric assessment should also be considered. Patients should feel empowered to advocate for themselves and have their views considered a part of the MDT discussion.

Akagündüz, Baran; Guven, Deniz Can; Ozer, Muhammet; Okten, Ilker Nihat; Atag, Elif; Unek, İlkay Tugba; Tatli, Ali Murat; Karaoglu, Aziz

Akagunduz, Baran; Martinez-Cannon, Bertha Alejandra; Mir, Nabiel; Velasco, Rogelio N.; Roy, Mukul; Liposits, Gabor

Chan, Wing-Lok; Marinho, Joana; Chavarri-Guerra, Yanin; Hincapie-Echeverri, Jacobo; Velasco, Rogelio N.; Akagunduz, Baran; Roy, Mukul; Kwong, Wing Tung Gobby; Wu, Wing-Fong; Battisti, Nicolò Matteo Luca

Breast cancer is the most common type of cancer affecting women worldwide and its risk increases with age. Compared with other breast cancer subtypes, triple negative breast cancer (TNBC) behaves more aggressively, with earlier relapses and poorer survival outcomes. Although the incidence of TNBC decreases with age, it still affects about 10% of older women with breast cancer. The management of TNBC in older patients is particularly challenging as chemotherapy is the main treatment choice in both early and advanced diseases and older patients are often prone to increased treatment-related toxicities. This review highlights the specific considerations in this vulnerable group of patients and summarizes the current evidence for TNBC management in older adults from early to late stage of disease.

Liposits, Gabor; Akagunduz, Baran; Rodgers, Lisa; Roy, Mukul; Velasco, Rogelio N.; Subbiah, Ishwaria M.; Marinho, Joana

Martinez-Cannon, Bertha Alejandra; Perez, Ana Cristina Torres; Hincapie-Echeverri, Jacobo; Roy, Mukul; Marinho, Joana; Buerba, Gabriela Alejandra; Akagunduz, Baran; Li, Daneng; Soto-Perez-de-Celis, Enrique

Anal cancer is an uncommon malignancy, however, its incidence has been increasing worldwide, including among older adults. The care of older patients with anal cancer requires a multidisciplinary and comprehensive team approach to ensure improved outcomes and maintenance of quality of life, and the geriatric assessment should be a key component in the evaluation of every older patient with anal cancer. Despite older adults representing a large proportion of patients with anal cancer, they were underrepresented in trials that defined currently accepted standard therapies, including definitive chemoradiotherapy. Nonetheless, data from retrospective studies suggest that fit older patients with anal cancer should receive standard treatment similarly to their younger counterparts. This review describes the current knowledge regarding the management of anal cancer in older adults, including geriatric assessment, localized, recurrent/persistent, and metastatic disease.