Şahin, Ali; Karataş, Beliz; Yalçın, İlker; Çelik, Neşe Çabuk; Pire, Gizem; Eren, Hatice Seyma; Karakaş, Burak; Kuzu, Merve Şenol; Yildirim, Merve; Özdamar, Burcu Nur

Objective: Considering that the group of rheumatological patients generally consists of women in their reproductive period due to hormonal effects, we aimed to investigate the effects of the treatments given to prevent joint and organ damage caused by these diseases on pregnancy and fertilization. Methods: This study included 1,000 female patients who were followed up due to rheumatological diseases at the rheumatology department of the internal medicine department of our hospital between January 2014 and January 2021. The patients’ ages, rheumatological disease diagnoses, pregnancy status, abortion status, curettage status, medications used, medications used during pregnancy, pregnancy complications, infertility data were retrospectively analyzed. Results: The number of patients who became pregnant after diagnosis increased with the use of colchicine and anakinra, while it decreased with the use of methotrexate and leflunomide. It was observed that the number of abortions before diagnosis increased in the presence of antiphospholipid antibody syndrome (APS) and systemic lupus erythematosus. It was determined that the number of patients giving live births decreased in the presence of an APS diagnosis. It was determined that the number of patients who had live births with the use of colchicine and hydroxychloroquine during pregnancy increased. Conclusion: It should be considered that women of reproductive age with rheumatic diseases may desire pregnancy and may present to the clinic with either planned or unplanned pregnancies during their follow-ups, and accordingly, efforts should be made to avoid medications that could cause infertility as much as possible.

Senturk, Esra; Ustundag, Hilal

Objective: High ambient temperature beyond the comfort zone causes environmental heat stress (HS). A large number of free radicals are produced as a response to stress. This situation can cause morbidity and mortality in humans and animals. The current study was conducted to determine the effects of HS on antioxidant status, immune response and related factors. Methods: In the study, 18 Sprague Dawley male rats were used as animal materials. Rats were randomly assigned to Thermo-neutral group (TN; untreated at normal ambient temperature of 24±2 °C), Heat-stress 1 group (HS1; 8 hours daily exposure at 30 °C) and Heat-stress 2 group (HS2; 8 hours daily exposure at 35 °C). At the end of HS application (day 14), rats were sacrificed under ether anesthesia and brain, duodenum, heart, liver, thyroid and testis tissues were taken. The biochemical and inflammatory responses of the tissues were analyzed with the ELISA Kit. Results: Compared to the control group; Myeloperoxidase activity was higher in the heart tissue of HS2 group (p<0.05). Superoxide dismutaz activity was higher in the brain and testis tissues in HS2 group (p<0.05). Interleukin (IL)-2 level was higher in the duodenum and testis tissue of HS1 group and lower in the liver tissue (p<0.05). IL-6 level was higher in the brain and heart tissue of HS2 group (p<0.05). Tumor necrosis factor-α concentration was lower in the brain tissue in HS1 group, higher in the duodenum tissue in HS2 group and testicular tissue in HS1 group (p<0.05). Conclusion: These results showed that HS adversely affected the oxidant/antioxidant status of brain, heart and testis tissues of rats and immune response of brain, duodenum, heart, liver and testis tissues; also showed that the negative effects of exposure to HS were related to the severity of the stress in the heart, liver and testicular tissues.

Asil, Talip; Özdemir Gültekin, Tuğçe; Eryiğit Baran, Gözde; Deniz, Çiğdem; Göktekin, Ömer; Aralaşmak, Ayşe

Genç yaşta görülen serebrovasküler hastalıkların sebepleri ara-sında ekstrakraniyal ve intrakraniyal arteriyel diseksiyonlar gi-derek daha sık tanımlanmaktadır. Genç erişkinde kalıcı sekel vemortalitenin söz konusu olduğu bu tablonun tedavisinde sıklıklaantikoagülan ilaçlar kullanılırken, giderek daha fazla hastada int-ravenöz trombolitik tedavi ve endovasküler tedavilerin uygulan-dığı bildirilmektedir. Bu yazıda akut ekstrakraniyal internal ka-rotis arter (ICA) diseksiyonu olan, intravenöz trombolitik tedavi(IVT) verilen, sonrasında atipik bir klinik seyir izleyen bir olguile birlikte ekstrakraniyal arter diseksiyonlarında agresif tedavile-rin etkinliği ve güvenilirliği tartışılmıştır.